Reactome | EPCAM [plasma membrane]

EPCAM [plasma membrane]

Stable Identifier

R-HSA-375068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor-associated calcium signal transducer 1, TACD1_HUMAN, TACSTD1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16422 EPCAM

Gene Names

EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1

Chain

signal peptide:1-23, chain:24-314

Reference Genes

BioGPS Gene:4072 EPCAM

COSMIC (genes):EPCAM EPCAM

CTD Gene:4072 EPCAM

dbSNP Gene:4072 EPCAM

ENSEMBL:ENSG00000119888 EPCAM

HGNC:11529 EPCAM

KEGG Gene (Homo sapiens):4072 EPCAM

Monarch:4072 EPCAM

NCBI Gene:4072 EPCAM

OMIM:185535 EPCAM

UCSC:P16422 EPCAM

Reference Transcript

RefSeq:NM_002354.2 EPCAM

Other Identifiers

11716887_a_at

11745651_a_at

11745652_s_at

16879863

201839_s_at

2480966

2480967

2480968

2480972

2480973

2480974

2480975

2480976

2480977

2480978

2480980

2480981

2480982

2480984

2480987

2480988

2480989

2753287

2753288

2753289

4072

575_s_at

8041853

8098439

A_14_P113932

A_23_P91081

GE60518

GO:0001657

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005923

GO:0007155

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009986

GO:0016020

GO:0016021

GO:0016323

GO:0016324

GO:0016328

GO:0023019

GO:0030054

GO:0030154

GO:0034641

GO:0040011

GO:0043066

GO:0043226

GO:0044877

GO:0045944

GO:0048856

GO:0048863

GO:0048870

GO:0050900

GO:0070062

GO:0098641

GO:0098742

GO:2000048

GO:2000147

GO:2000648

ILMN_1673871

ILMN_2160210

ILMN_3249032

M93036_at

PH_hs_0000078

TC02000293.hg

g4505058_3p_a_at

Participant Of

hasComponent

EPCAM dimer [plasma membrane]

input

EPCAM binds itself to form homotypic cell adhesion

Inferred To

TACSTD1 [plasma membrane] (Sus scrofa)

Epcam [plasma membrane] (Mus musculus)

Epcam [plasma membrane] (Rattus norvegicus)

EPCAM [plasma membrane] (Canis familiaris)

EPCAM [plasma membrane] (Gallus gallus)

EPCAM [plasma membrane] (Xenopus tropicalis)

epcam [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002345.2

OpenTargets

ENSG00000119888

HPA

ENSG00000119888-EPCAM

GeneCards

P16422

Ensembl

ENSG00000119888, ENST00000263735, ENSP00000263735

PRO

P16422

Orphanet

19023

PDB

6I07, 4MZV

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:Q15078 CDK5R1	4	CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2

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