Reactome | EPCAM [plasma membrane]

EPCAM [plasma membrane]

Stable Identifier

R-HSA-375068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor-associated calcium signal transducer 1, TACD1_HUMAN, TACSTD1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Enterobacteria (Homo sapiens)
      - Biofilm formation (Homo sapiens)
        
        Attachment of bacteria to epithelial cells (Homo sapiens)
        
        FimH binds D-mannose moiety on host cell (Homo sapiens)
        
        D-mannose bearing glycoproteins [plasma membrane] (Homo sapiens)
        
        EPCAM [plasma membrane] (Homo sapiens)
        
        FimH:D-mannose bearing glycoproteins [plasma membrane] (Homo sapiens)
        
        D-mannose bearing glycoproteins [plasma membrane] (Homo sapiens)
        
        EPCAM [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16422 EPCAM

Gene Names

EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1

Chain

signal peptide:1-23, chain:24-314

Reference Genes

BioGPS Gene:4072 EPCAM

COSMIC (genes):EPCAM EPCAM

CTD Gene:4072 EPCAM

dbSNP Gene:4072 EPCAM

ENSEMBL:ENSG00000119888 EPCAM

HGNC:11529 EPCAM

KEGG:hsa:4072 EPCAM

Monarch:4072 EPCAM

NCBI Gene:4072 EPCAM

OMIM:185535 EPCAM

UCSC:P16422 EPCAM

Reference Transcript

RefSeq:NM_002354.3 EPCAM

Other Identifiers

11716887_a_at

11745651_a_at

11745652_s_at

16879863

201839_PM_s_at

201839_s_at

2480962

2480965

2480966

2480967

2480968

2480969

2480970

2480971

2480972

2480973

2480974

2480975

2480976

2480977

2480978

2480980

2480981

2480982

2480984

2480985

2480987

2480988

2480989

2753287

2753288

2753289

4072

575_s_at

8041853

8098439

A_14_P113932

A_23_P91081

GE60518

GO:0001657

GO:0005515

GO:0005886

GO:0005923

GO:0006355

GO:0008284

GO:0009986

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0023019

GO:0030154

GO:0044877

GO:0045944

GO:0048856

GO:0048863

GO:0070062

GO:0070161

GO:0098609

GO:0098641

GO:2000048

GO:2000648

HMNXSV003057473

ILMN_2160209

ILMN_2160210

M93036_at

PH_hs_0000078

TC02000293.hg

g4505058_3p_a_at

Participates

as a member of

D-mannose bearing glycoproteins [plasma membrane] (Homo sapiens)

as a protein marker of

as a component of

EPCAM dimer [plasma membrane] (Homo sapiens)

as an input of

EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)

Inferred To

TACSTD1 [plasma membrane] (Sus scrofa)

Epcam [plasma membrane] (Mus musculus)

Epcam [plasma membrane] (Rattus norvegicus)

EPCAM [plasma membrane] (Bos taurus)

EPCAM [plasma membrane] (Canis familiaris)

EPCAM [plasma membrane] (Gallus gallus)

epcam [plasma membrane] (Danio rerio)

epcam [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002345.2

ENSEMBL

ENSG00000119888, ENST00000263735, ENSP00000263735

OpenTargets

ENSG00000119888

GeneCards

EPCAM

HPA

ENSG00000119888-EPCAM

PRO

P16422

Pharos - Targets

P16422

GlyGen

P16422

Orphanet

EPCAM

PDB

4MZV, 6I07

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12830 CDH1	20	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) PolyUbK48-CDH1 [plasma membrane] (R-HSA-9934660) PolyUbK48-CDH1 [early endosome membrane] (R-HSA-9934659) PolyUb-K740,K818-CDH1 [plasma membrane] (R-HSA-9935242) PolyUb-K740,K818-CDH1 [early endosome membrane] (R-HSA-9935416) PolyUb-K740,K818-CDH1 [lysosomal membrane] (R-HSA-9935544) Man,Man9GlucNAc2,p-3S,2Y-CDH1 [plasma membrane] (R-HSA-9934836) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932354) Man,Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9933097) Glu1Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932915) Glu2Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932341) Glu3Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932178) CDH1(23-882) [endoplasmic reticulum membrane] (R-HSA-9932157)	0.556	3
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	5
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.527	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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