Reactome | ATP1B3 [plasma membrane]

ATP1B3 [plasma membrane]

Stable Identifier

R-HSA-375073

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium/potassium-transporting ATPase subunit beta-3, AT1B3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1B [plasma membrane] (Homo sapiens)
        
        ATP1B3 [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1B [plasma membrane] (Homo sapiens)
        
        ATP1B3 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)
      - Basigin:Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)
        
        ATP1B3 [plasma membrane] (Homo sapiens)
      - Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)
        
        ATP1B3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54709 ATP1B3

Gene Names

ATP1B3

Chain

chain:1-279

Reference Genes

BioGPS Gene:483 ATP1B3

COSMIC (genes):ATP1B3 ATP1B3

CTD Gene:483 ATP1B3

dbSNP Gene:483 ATP1B3

ENSEMBL:ENSG00000069849 ATP1B3

HGNC:806 ATP1B3

KEGG:hsa:483 ATP1B3

Monarch:483 ATP1B3

NCBI Gene:483 ATP1B3

OMIM:601867 ATP1B3

UCSC:P54709 ATP1B3

Reference Transcript

RefSeq:NM_001679.4 ATP1B3

Other Identifiers

11744258_a_at

11744259_a_at

16946464

208836_PM_at

208836_at

229709_at

2555101

2645765

2645766

2645767

2645768

2645769

2645779

2645780

2645781

2645782

2645783

2645784

2645785

2645786

2645787

2645788

2645789

2645790

2645791

2645792

2645794

2645795

2645796

2645799

2645800

2645801

2645802

2645803

2645808

32563_at

42513_at

483

49934_at

77299_at

8083136

A_23_P68007

GE58262

GO:0001671

GO:0005515

GO:0005737

GO:0005886

GO:0005890

GO:0005929

GO:0006813

GO:0006814

GO:0006883

GO:0016020

GO:0016323

GO:0016324

GO:0030007

GO:0030674

GO:0031410

GO:0035725

GO:0036126

GO:0036376

GO:0042470

GO:0043226

GO:0050821

GO:0051117

GO:0055085

GO:0060090

GO:0070062

GO:0071805

GO:0072659

GO:0086009

GO:0098772

GO:0141109

GO:1903278

GO:1903288

GO:1990573

HMNXSV003013597

Hs.157112.0.A1_3p_at

ILMN_1654322

ILMN_1655783

ILMN_1741115

ILMN_1759628

ILMN_1783304

PH_hs_0031332

TC03000766.hg

U51478_at

g1522634_3p_at

Participates

as a member of

ATP1B [plasma membrane] (Homo sapiens)

as a component of

Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)

Inferred To

atp1b3 [plasma membrane] (Xenopus tropicalis)

nkb-3 [plasma membrane] (Caenorhabditis elegans)

nrv3 [plasma membrane] (Drosophila melanogaster)

atp1b3b [plasma membrane] (Danio rerio)

nrv2 [plasma membrane] (Drosophila melanogaster)

JYbeta2 [plasma membrane] (Drosophila melanogaster)

nkb-1 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG5250 [plasma membrane] (Drosophila melanogaster)

atp1b3a [plasma membrane] (Danio rerio)

Atp1b3 [plasma membrane] (Mus musculus)

Atp1b3 [plasma membrane] (Rattus norvegicus)

ATP1B3 [plasma membrane] (Bos taurus)

ATP1B3 [plasma membrane] (Canis familiaris)

ATP1B3 [plasma membrane] (Gallus gallus)

ATP1B3 [plasma membrane] (Sus scrofa)

Dmel\CG33310 [plasma membrane] (Drosophila melanogaster)

Homologues of ATP1B3 [plasma membrane] (Caenorhabditis elegans)

Homologues of ATP1B3 [plasma membrane] (Danio rerio)

Homologues of ATP1B3 [plasma membrane] (Drosophila melanogaster)

nkb-2 [plasma membrane] (Caenorhabditis elegans)

nrv1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001670.1

Guide to Pharmacology - Targets

839

ENSEMBL

ENST00000286371, ENSP00000286371, ENSG00000069849

OpenTargets

ENSG00000069849

GeneCards

ATP1B3

HPA

ENSG00000069849-ATP1B3

PRO

P54709

Pharos - Targets

P54709

GlyGen

P54709

HMDB Protein

HMDBP01199

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.643	3
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.527	2
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.527	2
UniProt:P04035 HMGCR	1	HMGCR [endoplasmic reticulum membrane] (R-HSA-9621345)	0.527	3
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2