Reactome: A Curated Pathway Database

Basigin binds CD98 complex

Stable Identifier
R-HSA-375131
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD97hc is a multifunctional glycoprotein with a single transmembrane domain, is highly expressed on proliferating cells, and functions as a chaperone for transporters. CD98hc forms disulfide-bonded heterodimers with at least seven different light chains (SLC7A5-11) that serve as amino acid transporters. Covalent cross-linking, mass spectrometric protein identification, and co-immunoprecipitation shows selective CD147 association with CD98hc complex.

Literature References
PubMed ID Title Journal Year
15901826 Metabolic activation-related CD147-CD98 complex Mol Cell Proteomics 2005
Participants
Participant Of
Orthologous Events