We will be undergoing a brief scheduled maintenance at Thursday Jan 18 at 10AM EST - you may experience some outages

We will be undergoing a scheduled maintenance at Thursday Jan 18 at 10AM EST

Basigin binds Matrix metalloproteinase-1

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Basigin (BSG, CD147, EMPRIN) is a glycoprotein expressed on the surface of most tumor cells. It stimulates stromal cells to produce elevated levels of several matrix metalloproteinases (MMP), including interstitial collagenase (MMP1). MMPs have been implicated in several aspects of tumor progression, including invasion through basement membranes and interstitial matrices, angiogenesis, and tumor cell growth. Basigin not only stimulates the production of MMP1 but also forms a complex with MMP1 at the tumor cell surface. This interaction may be important in modifying the tumor cell pericellular matrix to promote invasion.

Participant Of
Orthologous Events