Neogenin:Netrin-3 binds CDO complex

Stable Identifier
R-HSA-375141
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CDO selectively binds to neogenin in a cis fashion and this interaction involves extracellular domains of both proteins. CDO is essential in mediating netrin-3-induced differentiation of myoblasts by neogenin. Neogenin and netrin-3 stimulate myotube formation and enhance myogenic bHLH-and NFAT-dependent transcription.

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