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Interaction of NCAM1 with agrin
Stable Identifier
R-HSA-375155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1 with agrin (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Agrin, a Heparin Sulfate Proteoglycan (HSPG), plays a role in synaptogenesis and axonal growth. It interacts with NCAM1 both via NCAM's heparin binding domain in the IgII domain and through polysialic acid on the IgV domain.
Participants
Input
AGRN(30-2045) [extracellular region]
(Homo sapiens)
NCAM1 [plasma membrane]
(Homo sapiens)
Output
NCAM-1:Agrin [plasma membrane]
(Homo sapiens)
Participates
as an event of
NCAM1 interactions (Homo sapiens)
Inferred From
Interaction of NCAM1 with agrin (Gallus gallus)
Authored
Garapati, P V (2009-02-24)
Reviewed
Walmod, PS (2009-05-26)
Maness, PF (2009-05-26)
Created
Garapati, P V (2008-08-11)
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