Pannexin 1/Pannexin2 mediated neuronal gap junction communication

Stable Identifier
R-HSA-375339
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Pannexin 1/Pannexin2 mediated neuronal gap junction communication
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In this electrical synapse the current generated in the presynaptic cell spreads to the postsynaptic cell through an ion channel composed of two hemi-channels composed of six Pannexin 1 proteins on one hemi-channel and six Pannexin 2 proteins on the second.
Literature References
PubMed ID Title Journal Year
14597722 Pannexins, a family of gap junction proteins expressed in brain

Bruzzone, R, Herb, A, Barbe, MT, Hormuzdi, SG, Monyer, H

Proc Natl Acad Sci U S A 2003
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Catalyst Activity

gap junction channel activity of Pannexin 1/Pannexin 2 Gap Junction Complex [plasma membrane]

Physical Entity
Pannexin 1/Pannexin 2 Gap Junction Complex [plasma membrane] (Homo sapiens)
Activity
gap junction channel activity (GO:0005243)
Orthologous Events
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Sus scrofa)
Authored
Gillespie, ME  (2009-02-23)
Reviewed
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2008-08-26)
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