C5a receptor binds C5a anaphylatoxin

Stable Identifier
R-HSA-375395
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C5a (Fernandez HN and Hugli TE, 1978) is a protein fragment released from complement component C5. C5a is a potent anaphylatoxin, causing the release of histamine from mast cells and also being an effective leukocyte attractant. The C5a receptor (complement component 5a receptor 1, C5AR1; Cluster of Differentiation 88, CD88) (Gerard NP and Gerard C, 1991) mediates the pro-inflammatory and chemotactic actions of C5a.

Literature References
PubMed ID Title Journal Year
1847994 The chemotactic receptor for human C5a anaphylatoxin

Gerard, NP, Gerard, C

Nature 1991
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created