Reactome | FPR1 [plasma membrane]

FPR1 [plasma membrane]

Stable Identifier

R-HSA-375450

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Formyl peptide receptor, fMet-Leu-Phe receptor, FPR1_HUMAN, FPR

Locations in the PathwayBrowser for interactor UniProt:Q63HN8 RNF213

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
        
        FPR is a receptor for formyl peptides (Homo sapiens)
        
        FPR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21462 FPR1

Gene Names

FPR1

Chain

chain:1-350

Reference Genes

BioGPS Gene:2357 FPR1

COSMIC (genes):FPR1 FPR1

CTD Gene:2357 FPR1

dbSNP Gene:2357 FPR1

ENSEMBL:ENSG00000171051 FPR1

HGNC:3826 FPR1

KEGG:hsa:2357 FPR1

Monarch:2357 FPR1

NCBI Gene:2357 FPR1

OMIM:136537 FPR1

UCSC:P21462 FPR1

Reference Transcript

Other Identifiers

11758095_s_at

11762622_at

16874945

205118_PM_at

205118_at

205119_PM_s_at

205119_s_at

2357

36919_r_at

3729270

3869238

3869239

3869240

3869241

3869242

3869243

3869244

3869245

3869246

3869247

3869248

3869258

8038899

GE61934

GO:0001664

GO:0002376

GO:0002430

GO:0004875

GO:0004930

GO:0004982

GO:0005124

GO:0005515

GO:0005737

GO:0005886

GO:0006935

GO:0006954

GO:0007154

GO:0007165

GO:0007186

GO:0007188

GO:0007200

GO:0007204

GO:0007263

GO:0016020

GO:0023052

GO:0030667

GO:0035577

GO:0050786

GO:0101003

HMNXSV003007608

ILMN_2092118

M60626_at

PH_hs_0028688

PH_hs_0035311

TC19001787.hg

g4503778_3p_a_at

Participates

as a member of

as an input of

FPR is a receptor for formyl peptides (Homo sapiens)

as a component of

FPR1:FMLP [plasma membrane] (Homo sapiens)

Other forms of this molecule

FPR1 [ficolin-1-rich granule membrane]

FPR1 [secretory granule membrane]

FPR1 [azurophil granule membrane]

Inferred To

fpr1 [plasma membrane] (Danio rerio)

cmklr1l1 [plasma membrane] (Danio rerio)

Fpr1 [plasma membrane] (Mus musculus)

Fpr1 [plasma membrane] (Rattus norvegicus)

Homologues of FPR1 [plasma membrane] (Danio rerio)

Homologues of FPR1 [plasma membrane] (Xenopus tropicalis)

si:dkey-42l23.4 [plasma membrane] (Danio rerio)

LOC100489149 [plasma membrane] (Xenopus tropicalis)

LOC100491504 [plasma membrane] (Xenopus tropicalis)

si:dkey-117a8.1 [plasma membrane] (Danio rerio)

si:dkey-42l23.7 [plasma membrane] (Danio rerio)

LOC108648117 [plasma membrane] (Xenopus tropicalis)

FPR2 [plasma membrane] (Canis familiaris)

LOC101732071 [plasma membrane] (Xenopus tropicalis)

LOC108648060 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001180235.1, NP_002020.1

ZINC - World Drugs

FPR1_HUMAN

Guide to Pharmacology - Targets

222

OpenTargets

ENSG00000171051

ENSEMBL

ENSP00000472936, ENST00000595042, ENSP00000470750, ENST00000304748, ENSP00000471493, ENSG00000171051, ENST00000594900, ENST00000600815, ENSP00000302707

ZINC - Substances

FPR1_HUMAN

ZINC target

P21462

PRO

P21462

GlyGen

P21462

PDB

7T6T, 7VFX, 7WVU, 7EUO

GeneCards

FPR1

HPA

ENSG00000171051-FPR1

Pharos - Targets

P21462

Orphanet

FPR1

HMDB Protein

HMDBP02151

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.527	2
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.527	2
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.527	2
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.527	3
UniProt:Q92538 GBF1	4	GBF1 [cytosol] (R-HSA-6807751) GBF1 [endoplasmic reticulum lumen] (R-HSA-9947748) GBF1 [lipid droplet] (R-HSA-9954446) GBF1 [Golgi membrane] (R-HSA-199994)	0.527	2
UniProt:Q8WTW3 COG1	3	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9921505) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	3
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.527	2
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.527	2
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.527	3
UniProt:Q6PJG6 BRAT1			0.527	3
UniProt:O60287 NPA1P			0.527	2
UniProt:Q9UPU5 USP24	1	USP24 [nucleoplasm] (R-HSA-5697004)	0.527	2
UniProt:Q8IZQ1 WDFY3			0.527	2
UniProt:Q5T160 RARS2	1	RARS2 [mitochondrial matrix] (R-HSA-379589)	0.527	3
UniProt:O94829 IPO13			0.527	3
UniProt:Q9UI26 IPO11			0.527	3
UniProt:Q9Y5L0 TNPO3			0.527	2
UniProt:O14981 BTAF1			0.527	2
UniProt:Q86Y56 DAAF5			0.527	3
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:Q96GQ5 RUSF1			0.527	2
UniProt:Q9UIA9 XPO7			0.527	3
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	3
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:Q66K14 TBC9B			0.527	2
UniProt:Q96JI7 SPTCS			0.527	2
UniProt:Q8IWB1 IPRI			0.527	2
UniProt:Q9H9E3 COG4	2	COG4 [trans-Golgi network membrane] (R-HSA-6813868) COG4 [Golgi membrane] (R-HSA-6808722)	0.527	2
UniProt:Q9UGJ1 TUBGCP4	1	TUBGCP4 [cytosol] (R-HSA-379268)	0.527	2
UniProt:O43299 AP5Z1			0.527	2
UniProt:O43156 TTI1			0.527	3
UniProt:Q8N3P4 VPS8			0.527	2
UniProt:Q6NXR4 TTI2			0.527	3
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:O94874 UFL1	1	UFL1 [cytosol] (R-HSA-5688970)	0.527	2
UniProt:Q9NZ08 ERAP1	1	ERAP1 [endoplasmic reticulum lumen] (R-HSA-947609)	0.527	3
UniProt:P42356 PI4KA	1	PI4KA [cytosol] (R-HSA-1604653)	0.527	2
UniProt:O15264 MAPK13	2	p-T180,Y182-MAPK13 [cytosol] (R-HSA-171022) MAPK13 [cytosol] (R-HSA-171012)	0.499	3
UniProt:P25098 GRK2	4	GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.499	3

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