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VDR [nucleoplasm]
Stable Identifier
R-HSA-375512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NR1I1, VDR_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13573
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
1,25(OH)2D binds VDR (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
VDR agonists bind VDR (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11473 VDR
Gene Names
VDR, NR1I1
Chain
chain:1-427
Reference Genes
BioGPS Gene:7421 VDR
COSMIC (genes):VDR VDR
CTD Gene:7421 VDR
dbSNP Gene:7421 VDR
ENSEMBL:ENSG00000111424 VDR
ENSEMBL_homo_sapiens_GENE:ENSG00000111424.12 VDR
HGNC:12679 VDR
KEGG Gene (Homo sapiens):7421 VDR
Monarch:7421 VDR
NCBI Gene:7421 VDR
OMIM:601769 VDR
UCSC:P11473 VDR
Reference Transcript
RefSeq:NM_001017535.1 VDR
RefSeq:NM_001017536.1 VDR
RefSeq:XM_011538720.2 VDR
RefSeq:NM_000376.2 VDR
RefSeq:XM_006719587.3 VDR
Other Identifiers
11728776_s_at
11728777_a_at
11750983_a_at
11758546_x_at
1388_g_at
1410_at
16763764
204253_PM_s_at
204253_s_at
204254_PM_s_at
204254_s_at
204255_PM_s_at
204255_s_at
3452817
3452819
3452820
3452821
3452822
3452824
3452825
3452827
3452831
3452833
3452835
3452848
3452849
57460_at
7421
7962689
A_23_P162589
GE57479
GO:0000122
GO:0000785
GO:0000902
GO:0000978
GO:0000981
GO:0001501
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006816
GO:0006874
GO:0007595
GO:0008270
GO:0008285
GO:0008289
GO:0009887
GO:0010628
GO:0010839
GO:0010980
GO:0012501
GO:0016071
GO:0022414
GO:0022600
GO:0023052
GO:0030154
GO:0030501
GO:0030522
GO:0035435
GO:0038183
GO:0038186
GO:0042789
GO:0043226
GO:0043235
GO:0043565
GO:0045618
GO:0045892
GO:0045944
GO:0046697
GO:0046872
GO:0046965
GO:0048856
GO:0050892
GO:0055065
GO:0055085
GO:0060057
GO:0060058
GO:0060089
GO:0060558
GO:0060745
GO:0070561
GO:0070564
GO:0070644
GO:0090575
GO:0140110
GO:1902098
GO:1902121
GO:1903412
HMNXSV003010726
HMNXSV003043975
Hs.2062.0.A2_3p_a_at
Hs.2062.0.A3_3p_a_at
ILMN_1869034
ILMN_2319952
J03258_at
PH_hs_0000277
TC12001439.hg
TC12002858.hg
g4507882_3p_a_at
Participates
as a member of
NR [nucleoplasm] (Homo sapiens)
as an input of
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR agonists bind VDR (Homo sapiens)
1,25(OH)2D binds VDR (Homo sapiens)
as a component of
VDR:VDR agonists [nucleoplasm] (Homo sapiens)
1,25(OH)2D:VDR [nucleoplasm] (Homo sapiens)
Other forms of this molecule
polySUMO2-VDR [nucleoplasm]
Inferred To
nhr-8 [nucleoplasm]
(Caenorhabditis elegans)
vdr [nucleoplasm]
(Xenopus tropicalis)
daf-12 [nucleoplasm]
(Caenorhabditis elegans)
nhr-48 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of VDR [nucleoplasm]
(Caenorhabditis elegans)
VDR [nucleoplasm]
(Bos taurus)
VDR [nucleoplasm]
(Canis familiaris)
VDR [nucleoplasm]
(Danio rerio)
VDR [nucleoplasm]
(Gallus gallus)
VDR [nucleoplasm]
(Mus musculus)
VDR [nucleoplasm]
(Rattus norvegicus)
VDR [nucleoplasm]
(Sus scrofa)
Hr96 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_006719650.1
,
NP_000367.1
,
NP_001017535.1
,
XP_011537022.1
,
NP_001017536.1
ZINC - World Drugs
VDR_HUMAN
Guide to Pharmacology - Targets
605
OpenTargets
ENSG00000111424
ZINC - FDA approved
VDR_HUMAN
ZINC - Substances
VDR_HUMAN
ZINC target
P11473
ZINC - Biogenic
VDR_HUMAN
PRO
P11473
PDB
1IE8
,
3AZ3
,
5YT2
,
1S0Z
,
1KB6
,
1IE9
,
5V39
,
3AZ1
,
1KB2
,
3A2J
,
3A3Z
,
1KB4
,
3AZ2
,
2HB7
,
7QPP
,
3X36
,
3AUR
,
4G2I
,
3W0A
,
3A40
,
2HAR
,
2HAS
,
3W0Y
,
1S19
,
3AUQ
,
3TKC
,
3B0T
,
3M7R
,
3OGT
,
2HAM
,
4ITE
,
5YSY
,
3CS4
,
3CS6
,
1YNW
,
1DB1
,
3AX8
,
3A2I
,
3W0C
,
1TXI
,
3KPZ
,
2HB8
,
5GT4
,
3X31
,
3WGP
,
3P8X
,
3WWR
,
3A78
,
3VHW
,
4ITF
ZINC - Investigational
VDR_HUMAN
ZINC - Metabolites
VDR_HUMAN
GeneCards
P11473
HPA
ENSG00000111424-VDR
Ensembl
ENST00000550325
,
ENSP00000447173
,
ENST00000549336
,
ENSG00000111424
,
ENSP00000378734
,
ENST00000395324
,
ENSP00000449573
Pharos - Targets
P11473
Orphanet
15707
ZINC - Predictions - Purchasable
VDR_HUMAN
HMDB Protein
HMDBP01798
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.791
6
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.743
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.667
5
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.656
3
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.591
4
UniProt:P28700 Rxra
5
RXRA [cytosol]
(R-MMU-9619757)
phospho-p-S21-RXRA [nucleoplasm]
(R-MMU-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-MMU-4341130)
Rxra [nucleoplasm]
(R-MMU-442483)
RXRA [nucleoplasm]
(R-MMU-381319)
0.576
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q15645 PCH2
0.556
3
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.547
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.537
6
IntAct:EBI-9915211 CO1A1
0.524
2
UniProt:P26045 PTPN3
3
PTPN3 [plasma membrane]
(R-HSA-5490317)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [cytosol]
(R-HSA-8867650)
0.524
4
UniProt:Q15596 NCOA2
3
monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
(R-HSA-4085305)
NCOA2 (869-1464) [nucleoplasm]
(R-HSA-5603186)
NCOA2 [nucleoplasm]
(R-HSA-376398)
0.524
2
UniProt:Q9JLI4 NCOA6
0.508
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.499
2
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