Reactome | DLG1 [plasma membrane]

DLG1 [plasma membrane]

Stable Identifier

R-HSA-375977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SAP-97, Disks large homolog 1, DLG1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P06463 VE6

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        DLG1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12959 DLG1

Gene Names

DLG1

Chain

chain:1-904

Reference Genes

COSMIC (genes):DLG1 DLG1

dbSNP Gene:1739 DLG1

ENSEMBL:ENSG00000075711 DLG1

Participates

as a member of

PSD-95 family [plasma membrane] (Homo sapiens)

as a component of

as an output of

Trafficking of GluR1-containing AMPA receptors (Homo sapiens)

Other forms of this molecule

DLG1 [endoplasmic reticulum membrane]

DLG1 [transport vesicle membrane]

DLG1 [cytosol]

Inferred To

dlg1 [plasma membrane] (Drosophila melanogaster)

dlg1 [plasma membrane] (Xenopus tropicalis)

DLG1 [plasma membrane] (Bos taurus)

DLG1 [plasma membrane] (Canis familiaris)

DLG1 [plasma membrane] (Gallus gallus)

DLG1 [plasma membrane] (Sus scrofa)

dlg-1 [plasma membrane] (Caenorhabditis elegans)

dlg1l [plasma membrane] (Danio rerio)

Dlg1 [plasma membrane] (Mus musculus)

Dlg1 [plasma membrane] (Rattus norvegicus)

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06463 VE6			0.845	5
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.772	7
UniProt:P03126 VE6			0.722	3
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.704	4
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.702	5
UniProt:Q96KB5 TOPK			0.664	7
UniProt:P89079 E4OR1			0.656	4
UniProt:P78536 ADAM17	6	ADAM17 [plasma membrane] (R-HSA-179878) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763)	0.65	7
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.628	3
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.623	2
UniProt:Q9UQB3 CTND2			0.609	2
UniProt:P0C2L3 F163B			0.609	3
UniProt:Q14CM0 FRPD4			0.609	4
UniProt:P17386 VE6			0.609	2
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.609	2
UniProt:Q99569 PKP4	2	PKP4 [cornified envelope] (R-HSA-8847721) PKP4 [plasma membrane] (R-HSA-6814401)	0.609	3
UniProt:Q7Z628 NET1	1	NET1 [cytosol] (R-HSA-3006799)	0.609	5
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.59	3
UniProt:A1A5B4 ANO9	1	ANO9 [plasma membrane] (R-HSA-2684954)	0.573	2
UniProt:Q96PE1 AGRA2			0.573	2
UniProt:P06427 VE6			0.573	3
UniProt:P53778 MAPK12	3	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833)	0.571	2
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.564	2
UniProt:Q9C0D5 TANC1			0.558	3
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.543	10
UniProt:P36799 VE6			0.524	2
UniProt:O60333-3 KIF1B			0.508	4

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