Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ABL2 [cytosol]
Stable Identifier
R-HSA-375998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase ABL2, ABL2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Role of ABL in ROBO-SLIT signaling (Homo sapiens)
Activation of CLASP (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL:CLASP [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:p-Y1073-ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Recruitment of CAP to ABL (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL:CAP [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to ABL2 (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
active FLT3:ABL2 [plasma membrane] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42684 ABL2
Gene Names
ABL2, ABLL, ARG
Chain
initiator methionine:1, chain:2-1182
Reference Genes
BioGPS Gene:27 ABL2
COSMIC (genes):ABL2 ABL2
CTD Gene:27 ABL2
dbSNP Gene:27 ABL2
ENSEMBL:ENSG00000143322 ABL2
ENSEMBL:ENSG00000143322.22 ABL2
HGNC:77 ABL2
KEGG Gene (Homo sapiens):27 ABL2
Monarch:27 ABL2
NCBI Gene:27 ABL2
OMIM:164690 ABL2
UCSC:P42684 ABL2
Reference Transcript
RefSeq:NM_001136001.1 ABL2
RefSeq:XM_005245088.2 ABL2
RefSeq:NM_007314.3 ABL2
RefSeq:NM_005158.4 ABL2
RefSeq:NM_001136000.2 ABL2
RefSeq:NM_001168239.1 ABL2
RefSeq:NM_001168238.1 ABL2
RefSeq:NM_001168237.1 ABL2
RefSeq:NM_001168236.1 ABL2
Other Identifiers
1084_at
11740840_a_at
11741745_a_at
11742113_a_at
11743675_x_at
16696824
206411_PM_s_at
206411_s_at
226893_PM_at
226893_at
231907_3p_at
231907_PM_at
231907_at
2446044
2446046
2446048
2446049
2446050
2446051
2446052
2446053
2446054
2446055
2446056
2446057
2446058
2446059
2446060
2446061
2446062
2446064
2446066
2446067
2446069
2446071
2446072
2446073
2446088
2446089
2446090
2446091
2446092
27
2995316
53857_at
62243_i_at
62244_r_at
7922610
A_23_P138099
A_24_P263878
A_32_P139894
A_33_P3219601
A_33_P3413671
GE626229
GE88080
GO:0000166
GO:0000287
GO:0001784
GO:0002376
GO:0003785
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005856
GO:0006468
GO:0006914
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007204
GO:0008092
GO:0010506
GO:0010863
GO:0010976
GO:0012501
GO:0015629
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0023052
GO:0030100
GO:0030145
GO:0030154
GO:0030155
GO:0035024
GO:0035640
GO:0036211
GO:0042981
GO:0043226
GO:0046872
GO:0048856
GO:0048870
GO:0051015
GO:0051353
GO:0071300
GO:0140096
GO:1903905
GO:2000145
GO:2000249
GO:2000406
HMNXSV003023217
HMNXSV003032309
Hs.14763.0.A1_3p_at
Hs.159472.0.S1_3p_x_at
ILMN_1657870
ILMN_1741628
ILMN_2240003
M35296_at
PH_hs_0027902
TC01003566.hg
TC01005963.hg
g6382061_3p_a_at
Participates
as a candidate of
RAC1 effectors [cytosol] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
as a component of
active FLT3:ABL2 [plasma membrane] (Homo sapiens)
as an input of
Active FLT3 binds to ABL2 (Homo sapiens)
as a member of
ABL [cytosol] (Homo sapiens)
Inferred To
Abl2 [cytosol]
(Rattus norvegicus)
Homologues of ABL2 [cytosol]
(Caenorhabditis elegans)
ABL2 [cytosol]
(Bos taurus)
ABL2 [cytosol]
(Caenorhabditis elegans)
ABL2 [cytosol]
(Canis familiaris)
ABL2 [cytosol]
(Danio rerio)
ABL2 [cytosol]
(Drosophila melanogaster)
ABL2 [cytosol]
(Gallus gallus)
ABL2 [cytosol]
(Mus musculus)
ABL2 [cytosol]
(Sus scrofa)
ABL2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_009298.1
,
NP_001129472.1
,
NP_001161711.1
,
NP_001161710.1
,
NP_005149.4
,
XP_005245145.1
,
NP_001161708.1
,
NP_001161709.1
,
NP_001129473.1
ZINC - World Drugs
ABL2_HUMAN
Guide to Pharmacology - Targets
1924
OpenTargets
ENSG00000143322
ZINC - FDA approved
ABL2_HUMAN
ZINC - Substances
ABL2_HUMAN
ZINC - Biogenic
ABL2_HUMAN
ZINC target
P42684
PRO
P42684
PDB
4EIH
,
2KK1
,
3ULR
,
3GVU
,
3HMI
,
2XYN
,
5NP5
,
2ECD
,
5NP3
ZINC - Investigational
ABL2_HUMAN
IntEnz
2.7.10.2
HPA
ENSG00000143322-ABL2
GeneCards
P42684
Ensembl
ENST00000507173
,
ENST00000344730
,
ENSG00000143322
,
ENST00000511413
,
ENST00000512653
,
ENSP00000427562
,
ENSP00000424697
,
ENSP00000356595
,
ENST00000367623
,
ENSP00000339209
,
ENSP00000423578
,
ENST00000502732
,
ENSP00000426831
,
ENSP00000423413
,
ENST00000504405
Pharos - Targets
P42684
ZINC - Predictions - Purchasable
ABL2_HUMAN
HMDB Protein
HMDBP01329
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.702
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.692
9
UniProt:Q13671 RIN1
1
RIN1 [cytosol]
(R-HSA-8875287)
0.677
5
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [plasma membrane]
(R-HSA-167682)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.602
4
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.544
3
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.536
4
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
ChEBI:39112 BOSUTINIB
0.499
2
ChEBI:45783 IMATINIB
0.499
2
ChEBI:49375 DASATINIB
0.499
2
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.462
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text