Reactome | ABL2 [cytosol]

ABL2 [cytosol]

Stable Identifier

R-HSA-375998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ABL2, ABL2_HUMAN

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External Reference Information

External Reference

UniProt:P42684 ABL2

Gene Names

ABL2, ABLL, ARG

Chain

initiator methionine:1, chain:2-1182

Reference Genes

BioGPS Gene:27 ABL2

COSMIC (genes):ABL2 ABL2

CTD Gene:27 ABL2

dbSNP Gene:27 ABL2

ENSEMBL:ENSG00000143322 ABL2

HGNC:77 ABL2

KEGG Gene (Homo sapiens):27 ABL2

Monarch:27 ABL2

NCBI Gene:27 ABL2

OMIM:164690 ABL2

UCSC:P42684 ABL2

Reference Transcript

Other Identifiers

0001450605

0004540735

0104670064

04660+2.7.10.2

1084_at

11740840_a_at

11741745_a_at

11742113_a_at

11743675_x_at

16696824

17106

1866

206411_s_at

226893_at

231907_3p_at

231907_at

2446044

2446046

2446048

2446049

2446050

2446051

2446052

2446053

2446054

2446055

2446056

2446057

2446058

2446059

2446060

2446061

2446062

2446064

2446066

2446067

2446069

2446071

2446072

2446073

2446088

2446089

2446090

2446091

2446092

2995316

2ECD

2KK1

2XYN

3GVU

3HMI

3ULR

4EIH

53857_at

5NP3

5NP5

62243_i_at

62244_r_at

72754

7922610

A_23_P138099

A_24_P263878

A_32_P139894

A_33_P3219601

A_33_P3413667

A_33_P3413671

AAA35553

AAH65912

AAY16984

ABL2

ABL2-201

ABL2-202

ABL2-203

ABL2-204

ABL2-206

ABL2-207

ABL2-210

ABL2-211

ACK76601

ACK76602

ACK76603

ACK76604

AK311045

AL139132

AL359179

AL512326

BC065912

BX538317

CAB017106

CAD98092

CCDS30947

CCDS41441

CCDS44282

CCDS44283

CCDS53435

CCDS53436

CCDS53437

CCDS53438

CH471067

DQ009672

EAW91040

ENSG00000143322

ENSP00000339209

ENSP00000356595

ENSP00000375897

ENSP00000423413

ENSP00000423578

ENSP00000424697

ENSP00000426831

ENSP00000427562

ENST00000344730

ENST00000344730.7

ENST00000367623

ENST00000367623.8

ENST00000392043

ENST00000392043.3

ENST00000502732

ENST00000502732.5

ENST00000504405

ENST00000504405.5

ENST00000507173

ENST00000507173.5

ENST00000511413

ENST00000511413.5

ENST00000512653

ENST00000512653.5

EntrezGene:27

EntrezGene:ABL2

FJ542283

FJ542284

FJ542285

FJ542286

g6382061_3p_a_at

GE626229

GE88080

GO:0000166

GO:0000287

GO:0001784

GO:0003674

GO:0003785

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006810

GO:0006914

GO:0007010

GO:0007155

GO:0007165

GO:0007204

GO:0008092

GO:0008150

GO:0009056

GO:0010506

GO:0010863

GO:0010976

GO:0015629

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0030100

GO:0030145

GO:0030154

GO:0030155

GO:0035024

GO:0035640

GO:0040011

GO:0042592

GO:0043167

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0051015

GO:0051353

GO:0071300

GO:2000145

GO:2000249

HGNC:77

HPA001866

HPA072754

Hs.14763.0.A1_3p_at

Hs.159472.0.S1_3p_x_at

ILMN_1657870

ILMN_1741628

ILMN_1753972

ILMN_2240003

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR015015

IPR017441

IPR020635

IPR035837

IPR036028

IPR036860

M35296

M35296_at

MIM:164690

NM_001136000

NM_001136001

NM_001168236

NM_001168237

NM_001168238

NM_001168239

NM_005158

NM_007314

NP_001129472

NP_001129473

NP_001161708

NP_001161709

NP_001161710

NP_001161711

NP_005149

NP_009298

PF00017

PF00018

PF07714

PF08919

PH_hs_0027902

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

SM00808

TC01003566.hg

TC01005963.hg

UPI0000125140

UPI000023B7DF

UPI0000458861

UPI0000E56ED6

UPI0001823FDB

UPI000188F63F

UPI000188F6C9

UPI000188F6CA

XM_005245088

XM_017001035

XP_005245145

XP_016856524

Participant Of

hasMember

ABL [cytosol]

Inferred To

ABL2 [cytosol] (Bos taurus)

ABL2 [cytosol] (Caenorhabditis elegans)

ABL2 [cytosol] (Canis familiaris)

ABL2 [cytosol] (Danio rerio)

ABL2 [cytosol] (Drosophila melanogaster)

ABL2 [cytosol] (Gallus gallus)

ABL2 [cytosol] (Mus musculus)

ABL2 [cytosol] (Rattus norvegicus)

ABL2 [cytosol] (Sus scrofa)

ABL2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001161709.1, NP_001129473.1, NP_001161708.1, XP_005245145.1, NP_001129472.1, NP_005149.4, NP_001161711.1, NP_001161710.1, NP_009298.1

ZINC - World Drugs

ABL2_HUMAN

OpenTargets

ENSG00000143322

ZINC - FDA approved

ABL2_HUMAN

ZINC - Substances

ABL2_HUMAN

ZINC - Biogenic

ABL2_HUMAN

ZINC target

P42684

PRO

P42684

PDB

3ULR, 2XYN, 5NP3, 4EIH, 3HMI, 2ECD, 2KK1, 5NP5, 3GVU

ZINC - Investigational

ABL2_HUMAN

IntEnz

2.7.10.2

GeneCards

P42684

ZINC - Predictions - Purchasable

ABL2_HUMAN

HMDB Protein

HMDBP01329

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.702	5
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.592	8
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.589	4
UniProt:P36888 FLT3	2	Autophosphorylated FLT3 [plasma membrane] (R-HSA-9604780) FLT3 [plasma membrane] (R-HSA-6786756)	0.544	3
UniProt:P11142 HSPA8	10	HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2