Reactome | ABL2 [cytosol]

ABL2 [cytosol]

Stable Identifier

R-HSA-375998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ABL2, ABL2_HUMAN

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External Reference Information

External Reference

UniProt:P42684 ABL2

Gene Names

ABL2, ABLL, ARG

Chain

initiator methionine:1, chain:2-1182

Reference Genes

BioGPS Gene:27 ABL2

COSMIC (genes):ABL2 ABL2

CTD Gene:27 ABL2

dbSNP Gene:27 ABL2

ENSEMBL:ENSG00000143322 ABL2

HGNC:77 ABL2

KEGG Gene (Homo sapiens):27 ABL2

Monarch:27 ABL2

NCBI Gene:27 ABL2

OMIM:164690 ABL2

UCSC:P42684 ABL2

Reference Transcript

Other Identifiers

0001450605

0004540735

0104670064

1084_at

11740840_a_at

11741745_a_at

11742113_a_at

11743675_x_at

16696824

206411_s_at

226893_at

231907_3p_at

231907_at

2446044

2446046

2446048

2446049

2446050

2446051

2446052

2446053

2446054

2446055

2446056

2446057

2446058

2446059

2446060

2446061

2446062

2446064

2446066

2446067

2446069

2446071

2446072

2446073

2446088

2446089

2446090

2446091

2446092

2995316

53857_at

62243_i_at

62244_r_at

7922610

A_23_P138099

A_24_P263878

A_32_P139894

A_33_P3219601

A_33_P3413667

A_33_P3413671

GE626229

GE88080

GO:0000166

GO:0000287

GO:0001784

GO:0003674

GO:0003785

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006810

GO:0006914

GO:0007010

GO:0007155

GO:0007165

GO:0007204

GO:0008092

GO:0008150

GO:0009056

GO:0010506

GO:0010863

GO:0010976

GO:0015629

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0030100

GO:0030145

GO:0030154

GO:0030155

GO:0035024

GO:0035640

GO:0040011

GO:0042592

GO:0043167

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0051015

GO:0051353

GO:0071300

GO:2000145

GO:2000249

Hs.14763.0.A1_3p_at

Hs.159472.0.S1_3p_x_at

ILMN_1657870

ILMN_1741628

ILMN_1753972

ILMN_2240003

M35296_at

PH_hs_0027902

TC01003566.hg

TC01005963.hg

g6382061_3p_a_at

Participant Of

hasMember

ABL [cytosol]

Inferred To

Abl2 [cytosol] (Mus musculus)

Abl2 [cytosol] (Rattus norvegicus)

abl2 [cytosol] (Danio rerio)

abl2 [cytosol] (Xenopus tropicalis)

ABL2 [cytosol] (Canis familiaris)

ABL2 [cytosol] (Gallus gallus)

ABL2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001129473.1, NP_001161709.1, NP_001161710.1, XP_005245145.1, NP_001161708.1, NP_005149.4, NP_009298.1, NP_001161711.1, NP_001129472.1

ZINC - World Drugs

ABL2_HUMAN

OpenTargets

ENSG00000143322

ZINC - FDA approved

ABL2_HUMAN

ZINC - Substances

ABL2_HUMAN

ZINC - Biogenic

ABL2_HUMAN

ZINC target

P42684

PRO

P42684

PDB

3GVU, 2KK1, 3ULR, 2ECD, 5NP5, 3HMI, 4EIH, 2XYN, 5NP3

ZINC - Investigational

ABL2_HUMAN

IntEnz

2.7.10.2

GeneCards

P42684

HPA

ENSG00000143322-ABL2

Ensembl

ENST00000512653, ENST00000392043, ENST00000507173, ENSP00000375897, ENSP00000427562, ENSP00000426831, ENSP00000339209, ENST00000504405, ENSP00000423413, ENST00000502732, ENSP00000423578, ENSP00000424697, ENSG00000143322, ENST00000367623, ENST00000511413, ENSP00000356595, ENST00000344730

ZINC - Predictions - Purchasable

ABL2_HUMAN

HMDB Protein

HMDBP01329

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.702	5
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.692	9
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	4
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.589	4
UniProt:P36888 FLT3	2	FLT3 [plasma membrane] (R-HSA-6786756) Autophosphorylated FLT3 [plasma membrane] (R-HSA-9604780)	0.544	3
UniProt:P11142 HSPA8	10	HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2

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