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ABL2 [cytosol]
Stable Identifier
R-HSA-375998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase ABL2, ABL2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Role of ABL in ROBO-SLIT signaling (Homo sapiens)
Activation of CLASP (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL:CLASP [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:p-Y1073-ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
Recruitment of CAP to ABL (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL:CAP [plasma membrane] (Homo sapiens)
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
ABL [cytosol] (Homo sapiens)
ABL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42684 ABL2
Gene Names
ABL2, ABLL, ARG
Chain
initiator methionine:1, chain:2-1182
Reference Genes
BioGPS Gene:27 ABL2
COSMIC (genes):ABL2 ABL2
CTD Gene:27 ABL2
dbSNP Gene:27 ABL2
ENSEMBL:ENSG00000143322 ABL2
HGNC:77 ABL2
KEGG Gene (Homo sapiens):27 ABL2
Monarch:27 ABL2
NCBI Gene:27 ABL2
OMIM:164690 ABL2
UCSC:P42684 ABL2
Reference Transcript
RefSeq:NM_001168238.1 ABL2
RefSeq:NM_001168236.1 ABL2
RefSeq:NM_005158.4 ABL2
RefSeq:NM_001168237.1 ABL2
RefSeq:NM_001136000.2 ABL2
RefSeq:NM_001168239.1 ABL2
RefSeq:NM_007314.3 ABL2
RefSeq:NM_001136001.1 ABL2
RefSeq:XM_005245088.2 ABL2
Other Identifiers
0001450605
0004540735
0104670064
04660+2.7.10.2
1084_at
11740840_a_at
11741745_a_at
11742113_a_at
11743675_x_at
16696824
17106
1866
206411_s_at
226893_at
231907_3p_at
231907_at
2446044
2446046
2446048
2446049
2446050
2446051
2446052
2446053
2446054
2446055
2446056
2446057
2446058
2446059
2446060
2446061
2446062
2446064
2446066
2446067
2446069
2446071
2446072
2446073
2446088
2446089
2446090
2446091
2446092
27
2995316
2ECD
2KK1
2XYN
3GVU
3HMI
3ULR
4EIH
53857_at
5NP3
5NP5
62243_i_at
62244_r_at
72754
7922610
A_23_P138099
A_24_P263878
A_32_P139894
A_33_P3219601
A_33_P3413667
A_33_P3413671
AAA35553
AAH65912
AAY16984
ABL2
ABL2-201
ABL2-202
ABL2-203
ABL2-204
ABL2-206
ABL2-207
ABL2-210
ABL2-211
ACK76601
ACK76602
ACK76603
ACK76604
AK311045
AL139132
AL359179
AL512326
BC065912
BX538317
CAB017106
CAD98092
CCDS30947
CCDS41441
CCDS44282
CCDS44283
CCDS53435
CCDS53436
CCDS53437
CCDS53438
CH471067
DQ009672
EAW91040
ENSG00000143322
ENSP00000339209
ENSP00000356595
ENSP00000375897
ENSP00000423413
ENSP00000423578
ENSP00000424697
ENSP00000426831
ENSP00000427562
ENST00000344730
ENST00000344730.7
ENST00000367623
ENST00000367623.8
ENST00000392043
ENST00000392043.3
ENST00000502732
ENST00000502732.5
ENST00000504405
ENST00000504405.5
ENST00000507173
ENST00000507173.5
ENST00000511413
ENST00000511413.5
ENST00000512653
ENST00000512653.5
EntrezGene:27
EntrezGene:ABL2
FJ542283
FJ542284
FJ542285
FJ542286
g6382061_3p_a_at
GE626229
GE88080
GO:0000166
GO:0000287
GO:0001784
GO:0003674
GO:0003785
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006810
GO:0006914
GO:0007010
GO:0007155
GO:0007165
GO:0007204
GO:0008092
GO:0008150
GO:0009056
GO:0010506
GO:0010863
GO:0010976
GO:0015629
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0030100
GO:0030145
GO:0030154
GO:0030155
GO:0035024
GO:0035640
GO:0040011
GO:0042592
GO:0043167
GO:0043226
GO:0046872
GO:0048856
GO:0048870
GO:0051015
GO:0051353
GO:0071300
GO:2000145
GO:2000249
HGNC:77
HPA001866
HPA072754
Hs.14763.0.A1_3p_at
Hs.159472.0.S1_3p_x_at
ILMN_1657870
ILMN_1741628
ILMN_1753972
ILMN_2240003
IPR000719
IPR000980
IPR001245
IPR001452
IPR008266
IPR011009
IPR015015
IPR017441
IPR020635
IPR035837
IPR036028
IPR036860
M35296
M35296_at
MIM:164690
NM_001136000
NM_001136001
NM_001168236
NM_001168237
NM_001168238
NM_001168239
NM_005158
NM_007314
NP_001129472
NP_001129473
NP_001161708
NP_001161709
NP_001161710
NP_001161711
NP_005149
NP_009298
PF00017
PF00018
PF07714
PF08919
PH_hs_0027902
PR00109
PR00401
PR00452
SM00219
SM00252
SM00326
SM00808
TC01003566.hg
TC01005963.hg
UPI0000125140
UPI000023B7DF
UPI0000458861
UPI0000E56ED6
UPI0001823FDB
UPI000188F63F
UPI000188F6C9
UPI000188F6CA
XM_005245088
XM_017001035
XP_005245145
XP_016856524
Participant Of
hasMember
ABL [cytosol]
Inferred To
ABL2 [cytosol] (Bos taurus)
ABL2 [cytosol] (Caenorhabditis elegans)
ABL2 [cytosol] (Canis familiaris)
ABL2 [cytosol] (Danio rerio)
ABL2 [cytosol] (Drosophila melanogaster)
ABL2 [cytosol] (Gallus gallus)
ABL2 [cytosol] (Mus musculus)
ABL2 [cytosol] (Rattus norvegicus)
ABL2 [cytosol] (Sus scrofa)
ABL2 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001161709.1
,
NP_001129473.1
,
NP_001161708.1
,
XP_005245145.1
,
NP_001129472.1
,
NP_005149.4
,
NP_001161711.1
,
NP_001161710.1
,
NP_009298.1
ZINC - World Drugs
ABL2_HUMAN
OpenTargets
ENSG00000143322
ZINC - FDA approved
ABL2_HUMAN
ZINC - Substances
ABL2_HUMAN
ZINC - Biogenic
ABL2_HUMAN
ZINC target
P42684
PRO
P42684
PDB
3ULR
,
2XYN
,
5NP3
,
4EIH
,
3HMI
,
2ECD
,
2KK1
,
5NP5
,
3GVU
ZINC - Investigational
ABL2_HUMAN
IntEnz
2.7.10.2
GeneCards
P42684
ZINC - Predictions - Purchasable
ABL2_HUMAN
HMDB Protein
HMDBP01329
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.702
5
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.602
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.592
8
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.589
4
UniProt:P36888 FLT3
2
Autophosphorylated FLT3 [plasma membrane]
(R-HSA-9604780)
FLT3 [plasma membrane]
(R-HSA-6786756)
0.544
3
UniProt:P11142 HSPA8
10
HSPA8 [plasma membrane]
(R-HSA-936508)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
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