Reactome | ABL2 [cytosol]

ABL2 [cytosol]

Stable Identifier

R-HSA-375998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ABL2, ABL2_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P42684 ABL2

Gene Names

ABL2, ABLL, ARG

Chain

initiator methionine:1, chain:2-1182

Reference Genes

BioGPS Gene:27 ABL2

COSMIC (genes):ABL2 ABL2

CTD Gene:27 ABL2

dbSNP Gene:27 ABL2

ENSEMBL:ENSG00000143322 ABL2

ENSEMBL:ENSG00000143322.22 ABL2

HGNC:77 ABL2

KEGG Gene (Homo sapiens):27 ABL2

Monarch:27 ABL2

NCBI Gene:27 ABL2

OMIM:164690 ABL2

UCSC:P42684 ABL2

Reference Transcript

Other Identifiers

1084_at

11740840_a_at

11741745_a_at

11742113_a_at

11743675_x_at

16696824

206411_PM_s_at

206411_s_at

226893_PM_at

226893_at

231907_3p_at

231907_PM_at

231907_at

2446044

2446046

2446048

2446049

2446050

2446051

2446052

2446053

2446054

2446055

2446056

2446057

2446058

2446059

2446060

2446061

2446062

2446064

2446066

2446067

2446069

2446071

2446072

2446073

2446088

2446089

2446090

2446091

2446092

2995316

53857_at

62243_i_at

62244_r_at

7922610

A_23_P138099

A_24_P263878

A_32_P139894

A_33_P3219601

A_33_P3413671

GE626229

GE88080

GO:0000166

GO:0000287

GO:0001784

GO:0002376

GO:0003785

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005856

GO:0006468

GO:0006914

GO:0007010

GO:0007155

GO:0007163

GO:0007165

GO:0007204

GO:0008092

GO:0010506

GO:0010863

GO:0010976

GO:0012501

GO:0015629

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0023052

GO:0030100

GO:0030145

GO:0030154

GO:0030155

GO:0035024

GO:0035640

GO:0036211

GO:0042981

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0051015

GO:0051353

GO:0071300

GO:0140096

GO:1903905

GO:2000145

GO:2000249

GO:2000406

HMNXSV003023217

HMNXSV003032309

Hs.14763.0.A1_3p_at

Hs.159472.0.S1_3p_x_at

ILMN_1657870

ILMN_1741628

ILMN_2240003

M35296_at

PH_hs_0027902

TC01003566.hg

TC01005963.hg

g6382061_3p_a_at

Participates

as a candidate of

as a component of

active FLT3:ABL2 [plasma membrane] (Homo sapiens)

as an input of

Active FLT3 binds to ABL2 (Homo sapiens)

as a member of

ABL [cytosol] (Homo sapiens)

Inferred To

Abl2 [cytosol] (Rattus norvegicus)

Homologues of ABL2 [cytosol] (Caenorhabditis elegans)

ABL2 [cytosol] (Bos taurus)

ABL2 [cytosol] (Caenorhabditis elegans)

ABL2 [cytosol] (Canis familiaris)

ABL2 [cytosol] (Danio rerio)

ABL2 [cytosol] (Drosophila melanogaster)

ABL2 [cytosol] (Gallus gallus)

ABL2 [cytosol] (Mus musculus)

ABL2 [cytosol] (Sus scrofa)

ABL2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_009298.1, NP_001129472.1, NP_001161711.1, NP_001161710.1, NP_005149.4, XP_005245145.1, NP_001161708.1, NP_001161709.1, NP_001129473.1

ZINC - World Drugs

ABL2_HUMAN

Guide to Pharmacology - Targets

1924

OpenTargets

ENSG00000143322

ZINC - FDA approved

ABL2_HUMAN

ZINC - Substances

ABL2_HUMAN

ZINC - Biogenic

ABL2_HUMAN

ZINC target

P42684

PRO

P42684

PDB

4EIH, 2KK1, 3ULR, 3GVU, 3HMI, 2XYN, 5NP5, 2ECD, 5NP3

ZINC - Investigational

ABL2_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000143322-ABL2

GeneCards

P42684

Ensembl

ENST00000507173, ENST00000344730, ENSG00000143322, ENST00000511413, ENST00000512653, ENSP00000427562, ENSP00000424697, ENSP00000356595, ENST00000367623, ENSP00000339209, ENSP00000423578, ENST00000502732, ENSP00000426831, ENSP00000423413, ENST00000504405

Pharos - Targets

P42684

ZINC - Predictions - Purchasable

ABL2_HUMAN

HMDB Protein

HMDBP01329

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.702	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	9
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.677	5
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.602	4
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 F590_F605dup [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.544	3
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.536	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
ChEBI:39112 BOSUTINIB			0.499	2
ChEBI:45783 IMATINIB			0.499	2
ChEBI:49375 DASATINIB			0.499	2
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.462	2

Cite Us!