DSCAM/DSCAML1 homodimerization

Stable Identifier
R-HSA-376122
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DSCAM and DSCAML1 proteins are involved in homophilic intercellular interactions and these recognition events may play a role in neural connectivity. Recent studies in mouse demonstrate that DSCAM is selectively expressed in subclasses of cells and suggest that it uses homophilic repulsion to simultaneously promote both self avoidance (an essential developmental mechanism that allows axonal and dendrite processes to uniformly cover their synaptic fields) and tiling (ensures that the receptive fields of neurons from the same class do not overlap with one another) (Fuerst et al. 2008).

Literature References
PubMed ID Title Journal Year
18216854 Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina

Yamagata, M, Sanes, JR

Nature 2008
18216855 Neurite arborization and mosaic spacing in the mouse retina require DSCAM

Fuerst, PG, Koizumi, A, Masland, RH, Burgess, RW

Nature 2008
10925149 Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion

Agarwala, KL, Nakamura, S, Tsutsumi, Y, Yamakawa, K

Brain Res Mol Brain Res 2000
11453658 Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion

Agarwala, KL, Ganesh, S, Tsutsumi, Y, Suzuki, T, Amano, K, Yamakawa, K

Biochem Biophys Res Commun 2001
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