DSCAM associates with Rac1-GTP:pPAK1

Stable Identifier
R-HSA-376123
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DSCAM directly binds to serine/threonine-protein kinase PAK1 and this interaction is enhanced by the presence of Rac1 protein. Rac1 interacts with the CRIB motif in the N-terminal domain of PAK1 and DSCAM interacts with the kinase domain of PAK1. Rac1-bound PAK1, which is already active, has higher affinity for DSCAM, which may further regulate PAK1 activation.

Literature References
PubMed ID Title Journal Year
15169762 The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak

Li, W, Guan, KL

J Biol Chem 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created