Reactome | DSCAM interactions

DSCAM interactions

Stable Identifier

R-HSA-376172

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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DSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transmembrane and a C terminal cytoplasmic domain. DSCAM is implicated in Down syndrome (DS) due to the chromosomal location of the DSCAM gene, but no evidence supports a direct involvement of DSCAM with DS. It likely functions as a cell surface receptor mediating axon pathfinding. Besides these important implications, little is known about the physiological function or the molecular mechanism of DSCAM signal transduction in mammalian systems. A closely related DSCAM paralogue Down syndrome cell adhesion moleculelike protein 1 (DSCAML1) is present in humans. Both these proteins are involved in homophilic intercellular interactions.

Literature References

PubMed ID	Title	Journal	Year
18585357	DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1 Nikolaev, A, Ly, A, Stein, E, Zheng, Y, Tessier-Lavigne, M, Suresh, G	Cell	2008
10925149	Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion Agarwala, KL, Yamakawa, K, Tsutsumi, Y, Nakamura, S	Brain Res Mol Brain Res	2000