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NR2E1 [nucleoplasm]
Stable Identifier
R-HSA-376207
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor subfamily 2 group E member 1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
NR2E1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y466 NR2E1
Gene Names
NR2E1, TLX
Chain
chain:1-385
Reference Genes
BioGPS Gene:7101 NR2E1
COSMIC (genes):NR2E1 NR2E1
CTD Gene:7101 NR2E1
dbSNP Gene:7101 NR2E1
ENSEMBL:ENSG00000112333 NR2E1
HGNC:7973 NR2E1
KEGG:hsa:7101 NR2E1
Monarch:7101 NR2E1
NCBI Gene:7101 NR2E1
OMIM:603849 NR2E1
UCSC:Q9Y466 NR2E1
Reference Transcript
RefSeq:NM_003269.4 NR2E1
RefSeq:NM_001286102.1 NR2E1
Other Identifiers
11733365_a_at
11733366_a_at
17011397
207443_PM_at
207443_at
2920328
2920329
2920330
2920331
2920332
2920333
2920334
2920337
2920344
2920345
2920347
2920348
2920349
2920350
2920351
2920353
2920354
2920355
2920356
2920357
34125_at
7101
8121334
81508_at
A_14_P135140
A_23_P338372
GE678050
GE81256
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001525
GO:0001662
GO:0002052
GO:0002118
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006915
GO:0007399
GO:0007405
GO:0007420
GO:0007601
GO:0008270
GO:0008283
GO:0008284
GO:0012501
GO:0019899
GO:0021542
GO:0021764
GO:0021772
GO:0021819
GO:0021872
GO:0021895
GO:0021960
GO:0021987
GO:0030154
GO:0030182
GO:0030198
GO:0030522
GO:0035019
GO:0035176
GO:0042826
GO:0043010
GO:0043066
GO:0043226
GO:0043401
GO:0043565
GO:0043615
GO:0045165
GO:0045665
GO:0045766
GO:0045787
GO:0045944
GO:0046872
GO:0048708
GO:0048712
GO:0048814
GO:0048856
GO:0048870
GO:0050877
GO:0051128
GO:0060041
GO:0060089
GO:0060164
GO:0060291
GO:0061351
GO:0090049
GO:0140110
GO:1990837
GO:2000178
GO:2000179
GO:2000648
HMNXSV003025427
ILMN_1738580
ILMN_2094294
PH_hs_0001977
TC06000860.hg
TC06000861.hg
g11141398_3p_at
Participates
as a member of
NR [nucleoplasm] (Homo sapiens)
as a component of
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
Inferred To
Nr2e1 [nucleoplasm]
(Mus musculus)
Nr2e1 [nucleoplasm]
(Rattus norvegicus)
nr2e1 [nucleoplasm]
(Danio rerio)
nr2e1 [nucleoplasm]
(Xenopus tropicalis)
NR2E1 [nucleoplasm]
(Bos taurus)
NR2E1 [nucleoplasm]
(Canis familiaris)
NR2E1 [nucleoplasm]
(Gallus gallus)
NR2E1 [nucleoplasm]
(Sus scrofa)
nhr-67 [nucleoplasm]
(Caenorhabditis elegans)
tll [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003260.1
,
NP_001273031.1
Guide to Pharmacology - Targets
615
ENSEMBL
ENSP00000357979
,
ENST00000368986
,
ENSG00000112333
,
ENSP00000357982
,
ENST00000368983
OpenTargets
ENSG00000112333
GeneCards
NR2E1
HPA
ENSG00000112333-NR2E1
PRO
Q9Y466
Pharos - Targets
Q9Y466
PDB
4XAJ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.681
7
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.527
2
UniProt:Q8N4J0 CARNMT1
1
CARNMT1 [cytosol]
(R-HSA-8876689)
0.527
2
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.484
4
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