Reactome | MAPRE1 [cytosol]

MAPRE1 [cytosol]

Stable Identifier

R-HSA-376240

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EB1

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15691 MAPRE1

Gene Names

MAPRE1

Chain

initiator methionine:1, chain:2-268

Reference Genes

BioGPS Gene:22919 MAPRE1

COSMIC (genes):MAPRE1 MAPRE1

CTD Gene:22919 MAPRE1

dbSNP Gene:22919 MAPRE1

ENSEMBL:ENSG00000101367 MAPRE1

HGNC:6890 MAPRE1

KEGG Gene (Homo sapiens):22919 MAPRE1

Monarch:22919 MAPRE1

NCBI Gene:22919 MAPRE1

OMIM:603108 MAPRE1

UCSC:Q15691 MAPRE1

Reference Transcript

Other Identifiers

0005690092

11715586_at

11715587_at

16912625

19391

1PA7

1TXQ

1UEG

1VKA

1WU9

1YIB

1YIG

200712_s_at

200713_s_at

22919

2765329

2HKQ

2HL3

2HL5

2QJZ

2R8U

3155033

3155036

33456_at

3600

3882071

3882073

3882077

3882078

3882079

3882080

3882083

3882085

3882086

3882088

3GJO

3MTU

3MUD

3TQ7

4XA1

4XA3

4XA6

5JV3

5JVM

5JVP

5JVR

5JVS

5JVU

5JX1

5WLQ

8061772

9337

A_23_P40354

A_24_P220058

AAC09471

AAI06069

AAI09282

AK312590

AL035071

BAG35484

BC106068

BC109281

CAB009337

CAB019391

CCDS13208

CH471077

EAW76348

EAW76349

ENSG00000101367

ENSP00000364721

ENST00000375571

ENST00000375571.5

EntrezGene:22919

EntrezGene:MAPRE1

g6912493_3p_a_at

GE62755

GO:0000086

GO:0000278

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005881

GO:0005886

GO:0005925

GO:0007010

GO:0007049

GO:0008017

GO:0008022

GO:0008092

GO:0008104

GO:0008150

GO:0010389

GO:0015630

GO:0016477

GO:0019899

GO:0019901

GO:0022607

GO:0030335

GO:0030981

GO:0031110

GO:0031115

GO:0031116

GO:0031253

GO:0035371

GO:0035372

GO:0040011

GO:0042802

GO:0042995

GO:0043226

GO:0045296

GO:0048870

GO:0051010

GO:0051225

GO:0051233

GO:0051301

GO:0065003

GO:0070507

GO:0097711

GO:1903033

GO:1904825

GO:1905721

HGNC:6890

HPA003600

Hs.234279.0.S1_3p_a_at

ILMN_1777721

IPR001715

IPR004953

IPR027328

IPR027739

IPR036133

IPR036872

MAPRE1

MAPRE1-201

MIM:603108

NM_012325

NP_036457

PF00307

PF03271

PH_hs_0024767

TC20000216.hg

U24166

U24166_at

UPI000012EB1B

XM_011528696

XP_011526998

Participant Of

hasComponent

Inferred To

Homologues of MAPRE1 [cytosol] (Danio rerio)

MAPRE1 [cytosol] (Canis familiaris)

MAPRE1 [cytosol] (Danio rerio)

MAPRE1 [cytosol] (Dictyostelium discoideum)

MAPRE1 [cytosol] (Gallus gallus)

MAPRE1 [cytosol] (Mus musculus)

MAPRE1 [cytosol] (Plasmodium falciparum)

MAPRE1 [cytosol] (Rattus norvegicus)

MAPRE1 [cytosol] (Saccharomyces cerevisiae)

MAPRE1 [cytosol] (Schizosaccharomyces pombe)

MAPRE1 [cytosol] (Sus scrofa)

MAPRE1 [cytosol] (Xenopus tropicalis)

Ghost homologue of MAPRE1 [cytosol] (Bos taurus)

Cross References

RefSeq

NP_036457.1, XP_011526998.1

OpenTargets

ENSG00000101367

GeneCards

Q15691

PRO

Q15691

PDB

1YIG, 3GJO, 5JV3, 5JVU, 2R8U, 1YIB, 5JVP, 1UEG, 5JVR, 1VKA, 3MTU, 5JVS, 2HKQ, 3MUD, 4XA6, 5JX1, 5JVM, 1TXQ, 1WU9, 5WLQ, 4XA1, 2HL5, 4XA3, 2QJZ, 1PA7, 2HL3, 3TQ7

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14203 DCTN1	1	DCTN1 [cytosol] (R-HSA-535580)	0.866	8
UniProt:P25054 APC	13	APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC R1450 [cytosol] (R-HSA-5251499) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC [nucleoplasm] (R-HSA-3361755) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015)	0.775	5
UniProt:P30622 CLIP1	1	CLIP1 [cytosol] (R-HSA-377732)	0.672	3
UniProt:P15924 DSP	4	DSP [ficolin-1-rich granule membrane] (R-HSA-6801396) DSP [cornified envelope] (R-HSA-8847736) DSP(?-?) [plasma membrane] (R-HSA-351843) DSP [plasma membrane] (R-HSA-201580)	0.639	7
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.633	5
UniProt:P17612 PRKACA	3	PRKACA [cytosol] (R-HSA-57844) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.527	2
UniProt:Q9Y366 IFT52	2	IFT52 [cilium] (R-HSA-5610387) IFT52 [ciliary tip] (R-HSA-5625360)	0.508	2
UniProt:P11021 HSPA5	6	HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190)	0.508	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.508	2
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.508	2
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.488	2