Reactome | MAPRE1 [cytosol]

MAPRE1 [cytosol]

Stable Identifier

R-HSA-376240

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EB1

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        MAPRE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15691 MAPRE1

Gene Names

MAPRE1

Chain

initiator methionine:1, chain:2-268

Reference Genes

BioGPS Gene:22919 MAPRE1

COSMIC (genes):MAPRE1 MAPRE1

CTD Gene:22919 MAPRE1

dbSNP Gene:22919 MAPRE1

ENSEMBL:ENSG00000101367 MAPRE1

HGNC:6890 MAPRE1

KEGG Gene (Homo sapiens):22919 MAPRE1

Monarch:22919 MAPRE1

NCBI Gene:22919 MAPRE1

OMIM:603108 MAPRE1

UCSC:Q15691 MAPRE1

Reference Transcript

Other Identifiers

0005690092

11715586_at

11715587_at

16912625

200712_PM_s_at

200712_s_at

200713_PM_s_at

200713_s_at

22919

2765329

3155033

3155036

33456_at

3882071

3882073

3882077

3882078

3882079

3882080

3882083

3882085

3882086

3882088

8061772

A_23_P40354

A_24_P220058

GE62755

GO:0000132

GO:0000278

GO:0001578

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005881

GO:0005886

GO:0005925

GO:0005929

GO:0007010

GO:0007049

GO:0007059

GO:0008017

GO:0008022

GO:0008092

GO:0008104

GO:0008150

GO:0015630

GO:0016477

GO:0019899

GO:0019901

GO:0022607

GO:0030981

GO:0031110

GO:0031115

GO:0031116

GO:0031253

GO:0035371

GO:0035372

GO:0036064

GO:0040011

GO:0042802

GO:0042995

GO:0043226

GO:0045296

GO:0046785

GO:0048870

GO:0051010

GO:0051225

GO:0051233

GO:0051276

GO:0051301

GO:0051315

GO:0065003

GO:0071539

GO:0097431

GO:0140014

GO:1902888

GO:1903033

GO:1904825

GO:1905515

GO:1905721

HMNXSV003054313

Hs.234279.0.S1_3p_a_at

ILMN_1777721

PH_hs_0024767

TC20000216.hg

U24166_at

g6912493_3p_a_at

Participates

as a component of

Inferred To

mapre1 [cytosol] (Xenopus tropicalis)

mal3 [cytosol] (Schizosaccharomyces pombe)

Mapre1 [cytosol] (Mus musculus)

Mapre1 [cytosol] (Rattus norvegicus)

BIM1 [cytosol] (Saccharomyces cerevisiae)

eb1 [cytosol] (Dictyostelium discoideum)

MAPRE1 [cytosol] (Bos taurus)

MAPRE1 [cytosol] (Canis familiaris)

MAPRE1 [cytosol] (Gallus gallus)

MAPRE1 [cytosol] (Plasmodium falciparum)

MAPRE1 [cytosol] (Sus scrofa)

mapre1b [cytosol] (Danio rerio)

Cross References

RefSeq

NP_036457.1, XP_011526998.1

OpenTargets

ENSG00000101367

HPA

ENSG00000101367-MAPRE1

GeneCards

Q15691

Ensembl

ENSP00000364721, ENST00000375571, ENSG00000101367

PRO

Q15691

Pharos - Targets

Q15691

PDB

1VKA, 1UEG, 5JX1, 3TQ7, 6YSH, 5JVM, 4XA6, 2QJZ, 2HKQ, 5JVP, 2HL3, 5JVR, 1WU9, 6YF5, 2HL5, 3GJO, 5JVS, 2R8U, 5JV3, 5JVU, 6PFP, 1PA7, 1YIG, 3MTU, 1YIB, 4XA1, 1TXQ, 4XA3, 3MUD, 6PF2, 5WLQ

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.863	8
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.775	5
UniProt:P30622 CLIP1	1	CLIP1 [cytosol] (R-HSA-377732)	0.672	3
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.633	5
UniProt:P15924 DSP	4	DSP [cornified envelope] (R-HSA-8847736) DSP [ficolin-1-rich granule membrane] (R-HSA-6801396) DSP(?-?) [plasma membrane] (R-HSA-351843) DSP [plasma membrane] (R-HSA-201580)	0.626	7
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.527	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.508	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.508	3
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.508	2
UniProt:Q9Y366 IFT52	2	IFT52 [ciliary tip] (R-HSA-5625360) IFT52 [cilium] (R-HSA-5610387)	0.508	2

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