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NR4A2 [nucleoplasm]
Stable Identifier
R-HSA-376305
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NR4A2_HUMAN, Nuclear receptor subfamily 4 group A member 2
Locations in the PathwayBrowser for interactor UniProt:P55273%20CDKN2D
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)
NR4A2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43354 NR4A2
Gene Names
NR4A2, NOT, NURR1, TINUR
Chain
chain:1-598
Reference Genes
BioGPS Gene:4929 NR4A2
COSMIC (genes):NR4A2 NR4A2
CTD Gene:4929 NR4A2
dbSNP Gene:4929 NR4A2
ENSEMBL:ENSG00000153234 NR4A2
ENSEMBL_homo_sapiens_GENE:ENSG00000153234.16 NR4A2
HGNC:7981 NR4A2
KEGG Gene (Homo sapiens):4929 NR4A2
Monarch:4929 NR4A2
NCBI Gene:4929 NR4A2
OMIM:601828 NR4A2
UCSC:P43354 NR4A2
Reference Transcript
RefSeq:NM_006186.3 NR4A2
RefSeq:XM_017004219.1 NR4A2
RefSeq:XM_005246622.3 NR4A2
Other Identifiers
11725631_a_at
11725632_at
11747474_a_at
16903897
204621_PM_s_at
204621_s_at
204622_PM_x_at
204622_x_at
216248_PM_s_at
216248_s_at
2582125
2582126
2582127
2582128
2582129
2582130
2582132
2582135
2582136
2582138
2582140
2582141
2582142
2582146
2582150
2582159
2582160
37623_at
4929
547_s_at
8055952
A_23_P131208
A_33_P3299066
GE79306
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001666
GO:0001764
GO:0001975
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007165
GO:0007399
GO:0008013
GO:0008270
GO:0008344
GO:0009791
GO:0010467
GO:0010468
GO:0012501
GO:0016607
GO:0021952
GO:0021953
GO:0021986
GO:0023052
GO:0030154
GO:0030182
GO:0030522
GO:0031668
GO:0032991
GO:0034599
GO:0035259
GO:0042053
GO:0042416
GO:0042417
GO:0042551
GO:0043226
GO:0043524
GO:0043565
GO:0043576
GO:0045444
GO:0045893
GO:0045944
GO:0046872
GO:0046965
GO:0046982
GO:0048856
GO:0048870
GO:0050896
GO:0051402
GO:0051866
GO:0060070
GO:0060089
GO:0071376
GO:0071542
GO:0140110
GO:1904948
GO:1990837
GO:2001234
HMNXSV003012286
HMNXSV003048877
Hs.82120.0.S1_3p_a_at
Hs.82120.1.S1_3p_a_at
ILMN_1782305
ILMN_2339955
PH_hs_0004696
S77154_s_at
TC02002445.hg
X75918_at
Participates
as an input of
PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)
as a member of
NR [nucleoplasm] (Homo sapiens)
Other forms of this molecule
polySUMO2,3-K558,K577-NR4A2 [nucleoplasm]
Inferred To
Hr38 [nucleoplasm]
(Drosophila melanogaster)
Nr4a2 [nucleoplasm]
(Mus musculus)
Nr4a2 [nucleoplasm]
(Rattus norvegicus)
nhr-6 [nucleoplasm]
(Caenorhabditis elegans)
nr4a2 [nucleoplasm]
(Xenopus tropicalis)
NR4A2 [nucleoplasm]
(Bos taurus)
NR4A2 [nucleoplasm]
(Canis familiaris)
NR4A2 [nucleoplasm]
(Danio rerio)
NR4A2 [nucleoplasm]
(Gallus gallus)
NR4A2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_006177.1
,
XP_005246679.1
,
XP_016859708.1
Guide to Pharmacology - Targets
630
OpenTargets
ENSG00000153234
ZINC - Substances
NR4A2_HUMAN
ZINC target
P43354
PRO
P43354
PDB
1OVL
,
7WNH
,
6DDA
,
5YD6
,
5Y41
,
6L6L
,
6L6Q
HPA
ENSG00000153234-NR4A2
GeneCards
P43354
Ensembl
ENST00000409572
,
ENSP00000389986
,
ENST00000339562
,
ENSG00000153234
,
ENST00000426264
,
ENSP00000386747
,
ENSP00000344479
Pharos - Targets
P43354
Orphanet
28527
ZINC - Predictions - Purchasable
NR4A2_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55273 CDKN2D
1
CDKN2D [cytosol]
(R-HSA-182580)
0.666
4
UniProt:Q5T2S8 ODAD2
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q5H9L2 TCAL5
0.524
2
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