Reactome | VAMP8 [plasma membrane]

VAMP8 [plasma membrane]

Stable Identifier

R-HSA-376365

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Vesicle-associated membrane protein 8, VAMP8_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - PICALM binds R-SNAREs (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP8 [plasma membrane] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)
      - VAMP8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BV40 VAMP8

Gene Names

VAMP8

Chain

chain:1-100

Reference Genes

BioGPS Gene:8673 VAMP8

COSMIC (genes):VAMP8 VAMP8

CTD Gene:8673 VAMP8

dbSNP Gene:8673 VAMP8

ENSEMBL:ENSG00000118640 VAMP8

HGNC:12647 VAMP8

KEGG:hsa:8673 VAMP8

Monarch:8673 VAMP8

NCBI Gene:8673 VAMP8

OMIM:603177 VAMP8

UCSC:Q9BV40 VAMP8

Reference Transcript

RefSeq:NM_003761.4 VAMP8

Other Identifiers

11717012_s_at

16882277

202546_PM_at

202546_at

2491662

2491663

2491667

2491668

2491669

2491670

2491671

2491672

2491673

2491675

32715_at

49686_s_at

8043197

8673

A_14_P129859

A_23_P28434

GE61583

GO:0005484

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006906

GO:0006914

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016240

GO:0019869

GO:0019905

GO:0030667

GO:0030669

GO:0030670

GO:0031201

GO:0031410

GO:0031901

GO:0031902

GO:0031982

GO:0035493

GO:0035577

GO:0035579

GO:0042589

GO:0043226

GO:0043933

GO:0046718

GO:0048471

GO:0051607

GO:0055037

GO:0055038

GO:0060090

GO:0061024

GO:0065003

GO:0070062

GO:0070254

GO:0070821

GO:0097352

GO:0098542

GO:0098594

GO:0098772

GO:1903076

GO:1903531

GO:1903595

HMNXSV003027198

ILMN_2190084

PH_hs_0010333

TC02000512.hg

g4507864_3p_at

Participates

as an output of

Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)

as a member of

Other forms of this molecule

VAMP8 [specific granule membrane]

VAMP8 [azurophil granule membrane]

VAMP8 [tertiary granule membrane]

VAMP8 [recycling endosome membrane]

VAMP8 [phagocytic vesicle membrane]

VAMP8 [clathrin-coated endocytic vesicle membrane]

VAMP8 [lysosomal membrane]

VAMP8 [Golgi membrane]

VAMP8 [cytoplasmic vesicle membrane]

VAMP8 [secretory granule membrane]

Inferred To

nSyb [plasma membrane] (Drosophila melanogaster)

sybB [plasma membrane] (Dictyostelium discoideum)

snb-5 [plasma membrane] (Caenorhabditis elegans)

Vamp8 [plasma membrane] (Mus musculus)

Vamp8 [plasma membrane] (Rattus norvegicus)

snb-2 [plasma membrane] (Caenorhabditis elegans)

sybA [plasma membrane] (Dictyostelium discoideum)

snb-6 [plasma membrane] (Caenorhabditis elegans)

Homologues of VAMP8 [plasma membrane] (Caenorhabditis elegans)

Homologues of VAMP8 [plasma membrane] (Dictyostelium discoideum)

Homologues of VAMP8 [plasma membrane] (Drosophila melanogaster)

snb-7 [plasma membrane] (Caenorhabditis elegans)

VAMP8 [plasma membrane] (Bos taurus)

VAMP8 [plasma membrane] (Canis familiaris)

VAMP8 [plasma membrane] (Sus scrofa)

snb-1 [plasma membrane] (Caenorhabditis elegans)

vamp8 [plasma membrane] (Danio rerio)

vamp8 [plasma membrane] (Xenopus tropicalis)

Syb [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_003752.2

OpenTargets

ENSG00000118640

ENSEMBL

ENSP00000263864, ENST00000263864, ENSG00000118640

HPA

ENSG00000118640-VAMP8

GeneCards

VAMP8

PRO

Q9BV40

Pharos - Targets

Q9BV40

PDB

7BV6, 4WY4

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.832	8
UniProt:P56962 STX17	1	STX17 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807769)	0.737	11
UniProt:Q86Y82 STX12			0.725	6
UniProt:O15400 STX7			0.669	5
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.643	4
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.643	3
UniProt:Q9UNK0 STX8			0.643	5
UniProt:O75558 STX11			0.643	4
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.527	2
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.527	4
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.527	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.527	2
UniProt:O88384	2	Vti1b [extracellular region] (R-MMU-8862983) Vti1b [platelet alpha granule lumen] (R-MMU-8862964)	0.527	3
UniProt:Q8N4C7 STX19			0.527	2

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