Reactome | NCOA6 [nucleoplasm]

NCOA6 [nucleoplasm]

Stable Identifier

R-HSA-376414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NCOA6_HUMAN, Activating signal cointegrator 2, ASC-2, PRIP

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
        
        NCOA6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14686 NCOA6

Gene Names

NCOA6, AIB3, KIAA0181, RAP250, TRBP

Chain

chain:1-2063

Reference Genes

BioGPS Gene:23054 NCOA6

COSMIC (genes):NCOA6 NCOA6

CTD Gene:23054 NCOA6

dbSNP Gene:23054 NCOA6

ENSEMBL:ENSG00000198646 NCOA6

ENSEMBL_homo_sapiens_GENE:ENSG00000198646.14 NCOA6

HGNC:15936 NCOA6

KEGG Gene (Homo sapiens):23054 NCOA6

Monarch:23054 NCOA6

NCBI Gene:23054 NCOA6

OMIM:605299 NCOA6

UCSC:Q14686 NCOA6

Reference Transcript

Other Identifiers

11744361_a_at

16918546

208979_PM_at

208979_at

23054

3512349

3903535

3903536

3903537

3903541

3903546

3903549

3903555

3903556

3903557

3903560

3903561

3903562

3903563

3903565

3903566

3903567

3903568

3903569

3903570

3903571

3903576

3903579

3903581

3903582

3903583

3903584

3903585

3903593

3903595

3903596

3903597

40411_at

8065776

A_23_P259135

D80003_at

GE61127

GO:0003682

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005829

GO:0006351

GO:0006352

GO:0006355

GO:0006974

GO:0007420

GO:0007507

GO:0009725

GO:0019899

GO:0030099

GO:0030154

GO:0030331

GO:0030374

GO:0035097

GO:0043226

GO:0043231

GO:0044666

GO:0045893

GO:0045944

GO:0046965

GO:0046966

GO:0048856

GO:0140110

HMNXSV003032440

HMNXSV003052398

ILMN_1695797

PH_hs_0025439

TC20000786.hg

g7140573_3p_at

Participates

as a member of

as an input of

as a component of

Inferred To

NCOA6 [nucleoplasm] (Bos taurus)

NCOA6 [nucleoplasm] (Canis familiaris)

NCOA6 [nucleoplasm] (Gallus gallus)

ncoa6 [nucleoplasm] (Xenopus tropicalis)

Ncoa6 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_054790.2, NP_001229468.1, NP_001305169.1

OpenTargets

ENSG00000198646

GeneCards

Q14686

HPA

ENSG00000198646-NCOA6

Ensembl

ENSP00000363929, ENST00000374796, ENSG00000198646, ENST00000359003, ENSP00000351894

PRO

Q14686

Pharos - Targets

Q14686

HMDB Protein

HMDBP10825

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.926	15
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.918	10
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.892	13
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.832	7
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.788	10
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.757	5
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.725	6
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.618	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.593	3
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.564	2
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2