Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane

Stable Identifier
R-HSA-376851
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] <=> malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol]
Locations in the PathwayBrowser
Summation

The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial alpha-ketoglutarate (2-oxoglutarate) and cytosolic malate. Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from studies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

Literature References
PubMed ID Title Journal Year
8597574 The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier

Bisaccia, F, Zara, V, Capobianco, L, Iacobazzi, V, Mazzeo, M, Palmieri, F

Biochim Biophys Acta 1996
16920706 Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier

Kabe, Y, Ohmori, M, Sinouchi, K, Tsuboi, Y, Hirao, S, Azuma, M, Watanabe, H, Okura, I, Handa, H

J Biol Chem 2006
4687397 Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition

Sluse, FE, Goffart, G, Liébecq, C

Eur J Biochem 1973
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed