Reactome: A Curated Pathway Database

Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane

Stable Identifier
R-HSA-376851
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] <=> malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol]
Locations in the PathwayBrowser
Summation

The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial alpha-ketoglutarate (2-oxoglutarate) and cytosolic malate. Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from studies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane] SLC25A11 homodimer [mitochondrial inner membrane] oxoglutarate:malate antiporter activity (0015367)
Orthologous Events