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pS20-CBY1 [cytosol]
Stable Identifier
R-HSA-3769354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARB1, CBY, PGEA1, C22orf2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Homo sapiens)
pS20-CBY1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18573912
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
Mofunanya, A
,
Harris, K
,
Takemaru, K
,
Li, FQ
J. Cell Biol.
2008
External Reference Information
External Reference
UniProt:Q9Y3M2 CBY1
Gene Names
CBY1, ARB1, C22orf2, CBY, PGEA1, HRIHFB2025
Chain
chain:1-126
Reference Genes
BioGPS Gene:25776 CBY1
COSMIC (genes):CBY1 CBY1
CTD Gene:25776 CBY1
dbSNP Gene:25776 CBY1
ENSEMBL:ENSG00000100211 CBY1
HGNC:1307 CBY1
KEGG:hsa:25776 CBY1
Monarch:25776 CBY1
NCBI Gene:25776 CBY1
OMIM:607757 CBY1
UCSC:Q9Y3M2 CBY1
Reference Transcript
RefSeq:NM_015373.3 CBY1
RefSeq:NM_001002880.1 CBY1
Other Identifiers
11719193_a_at
16930077
203450_PM_at
203450_at
25776
33406_at
3945350
3945351
3945352
3945354
3945355
3945356
3945357
3945358
3945359
3945361
3945362
3945363
3945364
3945365
3945366
3945368
3945369
3945370
3945373
8073022
A_24_P74571
GE62096
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005802
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0008013
GO:0008104
GO:0016607
GO:0030030
GO:0030154
GO:0030178
GO:0033504
GO:0036064
GO:0042802
GO:0042803
GO:0042995
GO:0043226
GO:0044782
GO:0045444
GO:0045892
GO:0048856
GO:0051289
GO:0055007
GO:0060070
GO:0060271
GO:0065003
GO:0090090
HMNXSV003014044
ILMN_1678484
ILMN_1730879
ILMN_2399571
PH_hs_0023862
g7656941_3p_at
Participates
as a component of
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Homo sapiens)
Other forms of this molecule
CBY1 [nucleoplasm]
pS20-CBY1 [nucleoplasm]
Inferred To
phospho-Cby [cytosol]
(Drosophila melanogaster)
phospho-cby1 [cytosol]
(Danio rerio)
phospho-cby1 [cytosol]
(Xenopus tropicalis)
phospho-CBY1 [cytosol]
(Bos taurus)
phospho-CBY1 [cytosol]
(Canis familiaris)
phospho-CBY1 [cytosol]
(Gallus gallus)
phospho-Cby1 [cytosol]
(Mus musculus)
phospho-Cby1 [cytosol]
(Rattus norvegicus)
Ghost homologue of pS20-CBY1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of pS20-CBY1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 20
Coordinate
20
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001002880.2
,
NP_056188.1
OpenTargets
ENSG00000100211
ENSEMBL
ENSP00000380026
,
ENST00000411557
,
ENST00000416285
,
ENST00000396811
,
ENST00000216029
,
ENSP00000413934
,
ENSP00000412260
,
ENSP00000216029
HPA
ENSG00000100211-CBY1
PRO
Q9Y3M2
Pharos - Targets
Q9Y3M2
PDB
4WRQ
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.725
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.725
5
UniProt:Q96M91 CFA53
0.675
4
UniProt:Q8IYY4 DZI1L
0.666
4
UniProt:A1XBS5 CBAR1
0.666
4
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.666
4
UniProt:A1XBS5-3 CIBAR1
0.556
3
UniProt:A6NK89 RASFA
0.556
3
UniProt:Q9H8Y8 GORASP2
2
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
GORASP2 [Golgi membrane]
(R-HSA-2422385)
0.556
3
UniProt:Q96MY7 F161B
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9H0I2 ENKD1
0.556
3
UniProt:Q6PF05-3 TTC23L
0.556
3
UniProt:Q5GJ75 TNFAIP8L3
1
TNFAIP8L3 [cytosol]
(R-HSA-8874462)
0.556
3
UniProt:Q99816 TSG101
1
TSG101 [endosome membrane]
(R-HSA-2980549)
0.556
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:O95302 FKBP9
1
FKBP9 [cytosol]
(R-HSA-391306)
0.527
2
UniProt:Q7KZI7 MARK2
0.508
2
UniProt:O43822 CF410
0.508
2
UniProt:Q96BP2 CHCHD1
1
CHCHD1 [mitochondrial inner membrane]
(R-HSA-5368208)
0.508
2
UniProt:P11908 PRPS2
1
PRPS2 [cytosol]
(R-HSA-58224)
0.508
2
UniProt:Q5SW79 CE170
0.508
2
UniProt:Q8N5F7 NKAP
1
NKAP [nucleoplasm]
(R-HSA-9769602)
0.508
2
UniProt:Q96N67 DOCK7
1
DOCK7 [cytosol]
(R-HSA-1012970)
0.508
2
UniProt:Q9NXN4 GDAP2
0.508
2
UniProt:Q6BDS2 BLT3A
0.508
2
UniProt:Q14244 MAP7
0.508
2
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.508
2
UniProt:Q9H2C0 GAN
1
GAN [cytosol]
(R-HSA-976014)
0.508
2
UniProt:Q14CB8 ARHGAP19
1
ARHGAP19 [cytosol]
(R-HSA-200767)
0.508
2
UniProt:Q5VUJ6 LRCH2
0.508
2
UniProt:Q8IWC1 MA7D3
0.508
2
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