Reactome: A Curated Pathway Database

CBY1 binds beta-catenin

Stable Identifier
R-HSA-3769383
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Chibby (CBY1) is a conserved 126 amino acid protein that acts as an antagonist to the canonical WNT signaling pathway. CBY1 binds to the C-terminal region of beta-catenin and inhibits beta-catenin-dependent signaling by competing for the TCF/LEF binding sites and by promoting beta-catenin nuclear export (Takemaru et al, 2003; Li et al, 2008; Li et al, 2010). Endogenous CBY1 and beta-catenin co-immunoprecipitate from HEK293 cells and overexpression of CBY1 reduces expression of a beta-catenin dependent reporter gene, supporting a functional role for the CBY1-beta-catenin interaction in vivo (Takemaru et al, 2003). Studies with CBY1 knockout mice show only a slight effect on expression of WNT-dependent target genes, however; more work will be required to fully elucidate the role of CBY1 in regulating endogenous WNT signaling (Veronina et al, 2009).

Literature References
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