YWHAZ and XPO1 mediate the nuclear export of beta-catenin

Stable Identifier
R-HSA-3769392
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

14-3-3/YWHAZ and XPO1 both contribute to the CBY1-mediated nuclear export of beta-catenin (Li et al, 2008; Li et al, 2010). The fate of the tripartite beta-catenin:CBY1:14-3-3/YWHAZ complex in the cytoplasm is unknown, although it may represent a reservoir of beta-catenin available for further signaling. CBY1 may remain associated with 14-3-3/YWHAZ in the cytoplasm, as 14-3-3/YWHAZ binding inhibits binding of alpha-importin to CBY1 (Li et al, 2010) . This suggests the presence of a phosphatase that dephosphorylates S20 on CBY1 to allow binding with alpha-importin and reimport into the nucleus.

Literature References
PubMed ID Title Journal Year
19940019 Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling

Li, FQ, Mofunanya, A, Fischer, V, Hall, J, Takemaru, K

Mol. Biol. Cell 2010
18573912 Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity

Li, FQ, Mofunanya, A, Harris, K, Takemaru, K

J. Cell Biol. 2008
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