YWHAZ binds p-CBY:CTNNB1

Stable Identifier
R-HSA-3769393
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

14-3-3 proteins, represented here as YWHAZ, bind directly to CBY1 after AKT-dependent phosphorylation of CBY1 serine 20. Tagged versions of beta-catenin, CBY1 and 14-3-3/YWHAZ expressed in HEK293 cells co-immunoprecipitate in a CBY1-phosphorylation dependent manner. 14-3-3/YWHAZ binding promotes sequestration of CBY1 and beta-catenin in the cytoplasm, thus antagonizing beta-catenin-dependent transcription (Li et al, 2008).

Literature References
Participants
Participant Of
Orthologous Events