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AKT phosphorylates CBY1

Stable Identifier
R-HSA-3769394
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CBY1 is phosphorylated in vitro at serine 20 by AKT1 and AKT2. In vivo, this phosphorylation is required for the export of beta-catenin from the nucleus, facilitated by the binding of 14-3-3/YWHAZ proteins to the pS20 residue of CBY1 (Li et al, 2008).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AKT1/2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events