Activated Akt1 phosphorylates AKT1S1 (PRAS40)

Stable Identifier
R-HSA-377186
Type
Reaction
Species
Homo sapiens
Compartment
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AKT1 phosphorylates AKT1S1 (PRAS40, Proline Rich Akt Substrate 40 kDa) at Thr-246. AKT1S1 is an inhibitory accessory protein of mTORC1. Phosphorylation of AKT1S1 by AKT releases the inhibition of mTORC1.

Literature References
PubMed ID Title Journal Year
18372248 Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

Wang, L, Harris, TE, Lawrence JC, Jr

J Biol Chem 2008
17517883 The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Oshiro, N, Takahashi, R, Yoshino, K, Tanimura, K, Nakashima, A, Eguchi, S, Miyamoto, T, Hara, K, Takehana, K, Avruch, J, Kikkawa, U, Yonezawa, K

J Biol Chem 2007
12524439 Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

Kovacina, KS, Park, GY, Bae, SS, Guzzetta, AW, Schaefer, E, Birnbaum, MJ, Roth, RA

J Biol Chem 2003
17277771 Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Vander Haar, E, Lee, SI, Bandhakavi, S, Griffin, TJ, Kim, DH

Nat Cell Biol 2007
17386266 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Sancak, Y, Thoreen, CC, Peterson, TR, Lindquist, RA, Kang, SA, Spooner, E, Carr, SA, Sabatini, DM

Mol Cell 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 [plasma membrane]
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Activity
Orthologous Events
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