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pp-DVL1 [cytosol]
Stable Identifier
R-HSA-3772396
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dvl-1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NOX1 complex:WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Unknown kinase phosphorylates p-DVL (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL binds RAC1:GTP (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)
NOX1 complex:WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
WNT5:FZD7:pp-DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
DAAM1 recruits GTP-bound RHOA (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:RHOA:GTP [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL binds DAAM1 (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
DAAM1 recruits GTP-bound RHOA (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:RHOA:GTP [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
DAAM1 recruits PFN1 (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:PFN1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL binds DAAM1 (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL recruits RAC (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
pp-DVL:RAC:GTP [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
ppDVL:PIP5K1B [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
ppDVL:PIP5K1B [cytosol] (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)
pp-DVL [cytosol] (Homo sapiens)
pp-DVL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14640 DVL1
Gene Names
DVL1
Chain
chain:1-695
Reference Genes
BioGPS Gene:1855 DVL1
COSMIC (genes):DVL1 DVL1
CTD Gene:1855 DVL1
dbSNP Gene:1855 DVL1
ENSEMBL:ENSG00000107404 DVL1
HGNC:3084 DVL1
KEGG Gene (Homo sapiens):1855 DVL1
Monarch:1855 DVL1
NCBI Gene:1855 DVL1
OMIM:601365 DVL1
UCSC:O14640 DVL1
Reference Transcript
RefSeq:NM_001330311.1 DVL1
RefSeq:NM_004421.2 DVL1
Other Identifiers
0000110170
0005130497
11723081_s_at
163_at
16680236
1855
203230_at
2391426
2391427
2391428
2391432
2391433
2391434
2391435
2391436
2391437
2391438
2391440
2391443
2391445
2391446
2391448
2391450
2391451
2391452
2391454
2391455
2391456
2391461
2391462
2391463
2391464
4044133
4044134
4044135
4044139
4044140
4044141
4044142
4044143
4044144
4044145
4044146
4044151
4044153
4044154
4044155
4044156
4044159
4044160
4044161
43392_at
45360_s_at
64927_at
7911506
A_23_P201342
A_23_P347432
GE61444
GO:0000902
GO:0001505
GO:0001932
GO:0001933
GO:0001934
GO:0003674
GO:0005109
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006355
GO:0006464
GO:0006469
GO:0006810
GO:0007010
GO:0007165
GO:0007267
GO:0007269
GO:0007275
GO:0007409
GO:0007411
GO:0007528
GO:0008013
GO:0008150
GO:0009056
GO:0009058
GO:0009790
GO:0010976
GO:0014069
GO:0015630
GO:0016020
GO:0016055
GO:0016328
GO:0019899
GO:0019901
GO:0021915
GO:0022007
GO:0022607
GO:0030136
GO:0030154
GO:0030424
GO:0030425
GO:0030426
GO:0031122
GO:0031410
GO:0032091
GO:0032436
GO:0032991
GO:0034330
GO:0034504
GO:0034641
GO:0035176
GO:0035372
GO:0035556
GO:0035567
GO:0040007
GO:0040011
GO:0042802
GO:0043005
GO:0043025
GO:0043113
GO:0043197
GO:0043226
GO:0045202
GO:0045944
GO:0048365
GO:0048646
GO:0048668
GO:0048675
GO:0048813
GO:0048856
GO:0050808
GO:0050821
GO:0050877
GO:0060029
GO:0060070
GO:0060071
GO:0060134
GO:0060997
GO:0061024
GO:0071340
GO:0090090
GO:0090103
GO:0090179
GO:0098793
GO:0098978
GO:0099054
GO:0150012
GO:1903827
GO:1904886
GO:1905386
GO:1990909
GO:2000463
ILMN_1655632
ILMN_1678564
ILMN_1783444
ILMN_3200492
PH_hs_0004245
TC01002092.hg
U46461_at
g2291005_3p_at
Participant Of
hasMember
pp-DVL [cytosol]
hasCandidate
pp-DVL [cytosol]
Other forms of this molecule
ub-DVL1 [cytosol]
DVL1 [cytosol]
p-S-DVL1 [cytosol]
Inferred To
phospho-dvl1b [cytosol] (Danio rerio)
phospho-Dvl1 [cytosol] (Mus musculus)
phospho-Dvl1 [cytosol] (Rattus norvegicus)
phospho-dsh [cytosol] (Drosophila melanogaster)
phospho-DVL1 [cytosol] (Bos taurus)
phospho-DVL1 [cytosol] (Canis familiaris)
phospho-DVL1 [cytosol] (Gallus gallus)
phospho-DVL1 [cytosol] (Sus scrofa)
phospho-dsh-2 [cytosol] (Caenorhabditis elegans)
phospho-dvl1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001317240.1
,
NP_004412.2
OpenTargets
ENSG00000107404
HPA
ENSG00000107404-DVL1
GeneCards
O14640
ZINC target
O14640
Ensembl
ENSP00000368169
,
ENST00000378891
,
ENSP00000368166
,
ENSG00000107404
,
ENST00000378888
PRO
O14640
Orphanet
23213
PDB
6TTK
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O70239 AXIN1
0.796
12
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.639
6
UniProt:Q92997 DVL3
4
p-DVL3 [cytosol]
(R-HSA-201680)
pp-DVL3 [cytosol]
(R-HSA-3772400)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.633
5
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
0.623
6
UniProt:Q9EQC9 Cxxc4
1
Cxxc4 [cytosol]
(R-RNO-5368460)
0.611
5
UniProt:Q6P3W7 SCYL2
0.544
4
UniProt:O14640 DVL1
4
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
p-S-DVL1 [cytosol]
(R-HSA-201700)
pp-DVL1 [cytosol]
(R-HSA-3772396)
0.524
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [cytosol]
(R-HSA-1629773)
WWTR1 [nucleoplasm]
(R-HSA-1629775)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
0.524
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.463
3
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.463
2
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