CTNNBIP1 binds beta-catenin

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).

Literature References
PubMed ID Title Journal Year
10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein

Tago, K, Nakamura, T, Nishita, M, Hyodo, J, Nagai, S, Murata, Y, Adachi, S, Ohwada, S, Morishita, Y, Shibuya, H, Akiyama, T

Genes Dev. 2000
12408824 The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT

Graham, TA, Clements, WK, Kimelman, D, Xu, W

Mol. Cell 2002
12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

Daniels, DL, Weis, WI

Mol. Cell 2002
Participant Of
Orthologous Events