CTNNBIP1 binds beta-catenin

Stable Identifier
R-HSA-3772430
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).

Participants
Participant Of
Orthologous Events