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PPP2R2A [cytosol]
Stable Identifier
R-HSA-377253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2A-regulatory subunit B55 alpha isoform
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
ANKLE2 binds PP2A (Homo sapiens)
ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
PP2A dephosphorylates BANF1 (Homo sapiens)
ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63151 PPP2R2A
Gene Names
PPP2R2A
Chain
initiator methionine:1, chain:2-447
Reference Genes
BioGPS Gene:5520 PPP2R2A
COSMIC (genes):PPP2R2A PPP2R2A
CTD Gene:5520 PPP2R2A
dbSNP Gene:5520 PPP2R2A
ENSEMBL:ENSG00000221914 PPP2R2A
HGNC:9304 PPP2R2A
KEGG Gene (Homo sapiens):5520 PPP2R2A
Monarch:5520 PPP2R2A
NCBI Gene:5520 PPP2R2A
OMIM:604941 PPP2R2A
UCSC:P63151 PPP2R2A
Reference Transcript
RefSeq:NM_001177591.1 PPP2R2A
RefSeq:NM_002717.3 PPP2R2A
Other Identifiers
0000670397
11756714_a_at
1383_at
202313_at
228013_at
3090938
3090939
3090940
3090941
3090943
3090944
3090956
3090961
3090964
3090967
3090972
3090973
3090975
3090982
3090983
3090988
3090989
3090990
3090991
3090992
3090993
3090994
3487899
41167_at
46187_at
5520
8145440
82421_i_at
82422_r_at
A_14_P123050
A_23_P123539
A_24_P346644
GE58038
GO:0000086
GO:0000159
GO:0000184
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0007049
GO:0007084
GO:0008092
GO:0008150
GO:0009056
GO:0019888
GO:0019899
GO:0030234
GO:0032991
GO:0034641
GO:0034655
GO:0043226
GO:0043278
GO:0043666
GO:0044877
GO:0045202
GO:0048156
GO:0051721
GO:0061024
GO:0070262
GO:0098978
Hs.61696.0.A1_3p_at
ILMN_1788961
M64929_at
PH_hs_0028631
g4506018_3p_at
Participant Of
hasComponent
PP2A (Aalpha:B55alpha:Calpha) [cytosol]
Other forms of this molecule
PPP2R2A [nucleoplasm]
Inferred To
tws [cytosol] (Drosophila melanogaster)
Homologues of PPP2R2A [cytosol] (Dictyostelium discoideum)
phr2aB [cytosol] (Dictyostelium discoideum)
CDC55 [cytosol] (Saccharomyces cerevisiae)
atrx [cytosol] (Xenopus tropicalis)
pab1 [cytosol] (Schizosaccharomyces pombe)
sur-6 [cytosol] (Caenorhabditis elegans)
Ghost homologue of PPP2R2A [cytosol] (Bos taurus)
Ghost homologue of PPP2R2A [cytosol] (Plasmodium falciparum)
Ghost homologue of PPP2R2A [cytosol] (Sus scrofa)
PPP2R2A [cytosol] (Canis familiaris)
PPP2R2A [cytosol] (Dictyostelium discoideum)
PPP2R2A [cytosol] (Gallus gallus)
Ppp2r2a [cytosol] (Mus musculus)
Ppp2r2a [cytosol] (Rattus norvegicus)
ppp2r2ab [cytosol] (Danio rerio)
Cross References
RefSeq
NP_001171062.1
,
NP_002708.1
OpenTargets
ENSG00000221914
GeneCards
P63151
HPA
ENSG00000221914-PPP2R2A
ZINC target
P63151
Ensembl
ENSP00000370113
,
ENST00000380737
,
ENST00000315985
,
ENSP00000325074
,
ENSG00000221914
PRO
P63151
PDB
3DW8
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.641
4
UniProt:Q15843 NEDD8
17
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
K1881-CUL9-G76-NEDD8 [cytosol]
(R-HSA-8955924)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
K705-CUL4A-G76-NEDD8 [nucleoplasm]
(R-HSA-8952528)
K859-CUL4B-G76-NEDD8 [nucleoplasm]
(R-HSA-8952538)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
K720-CUL1-G76-NEDD8 [cytosol]
(R-HSA-8952534)
K712-CUL3-G76-NEDD8 [cytosol]
(R-HSA-8952531)
K689-CUL2-G76-NEDD8 [cytosol]
(R-HSA-8952526)
K724-CUL5-G76-NEDD8 [cytosol]
(R-HSA-8952018)
NEDD8 [cytosol]
(R-HSA-416969)
K567-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419906)
K556-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419907)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:P62280 RPS11
2
RPS11 [cytosol]
(R-HSA-72327)
RPS11 [nucleoplasm]
(R-HSA-6791212)
0.462
2
UniProt:P46531 NOTCH1
60
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
p-NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2159809)
p-NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902204)
NOTCH1 L1574P Extracellular Fragment [extracellular region]
(R-HSA-1485582)
NOTCH1 L1600P Extracellular Fragment [extracellular region]
(R-HSA-2681764)
NEXT1 P2474Afs*4 [plasma membrane]
(R-HSA-2902194)
NEXT1 Q2395* [plasma membrane]
(R-HSA-2902192)
NEXT1 Q2440* [plasma membrane]
(R-HSA-2902196)
NEXT1 P2514Rfs*4 [plasma membrane]
(R-HSA-2768989)
NICD1 Q2395* [cytosol]
(R-HSA-2902195)
NICD1 P2514Rfs*4 [cytosol]
(R-HSA-2768996)
NICD1 P2474Afs*4 [cytosol]
(R-HSA-2902193)
NICD1 Q2440* [cytosol]
(R-HSA-2902191)
NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2769013)
NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902208)
NICD1 Q2395* [nucleoplasm]
(R-HSA-2902201)
NICD1 Q2440* [nucleoplasm]
(R-HSA-2902200)
NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2768982)
NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]
(R-HSA-1485596)
NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]
(R-HSA-1485602)
NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2894873)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region]
(R-HSA-2220929)
p-NICD1 [nucleoplasm]
(R-HSA-1604444)
Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911426)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911415)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911503)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane]
(R-HSA-1911511)
Pre-NOTCH1 [endoplasmic reticulum membrane]
(R-HSA-157024)
17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467396)
19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467425)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane]
(R-HSA-1472872)
NOTCH1(1665-2555) [Golgi membrane]
(R-HSA-157092)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane]
(R-HSA-1983679)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane]
(R-HSA-1911512)
NOTCH1(1665-2555) [plasma membrane]
(R-HSA-157239)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]
(R-HSA-1983670)
NOTCH1(1665-1720) [extracellular region]
(R-HSA-157654)
NOTCH1(1721-1753) [plasma membrane]
(R-HSA-157656)
NEXT1 [plasma membrane]
(R-HSA-157200)
NICD1 [cytosol]
(R-HSA-157634)
NICD1 [nucleoplasm]
(R-HSA-157939)
0.462
2
UniProt:Q8N163 CCAR2
2
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
DBC1 [nucleoplasm]
(R-HSA-3371479)
0.462
2
UniProt:P42285 MTREX
1
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
0.462
2
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