Reactome | PPP2R2A [cytosol]

PPP2R2A [cytosol]

Stable Identifier

R-HSA-377253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-regulatory subunit B55 alpha isoform

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 binds PP2A (Homo sapiens)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates BANF1 (Homo sapiens)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63151 PPP2R2A

Gene Names

PPP2R2A

Chain

initiator methionine:1, chain:2-447

Reference Genes

BioGPS Gene:5520 PPP2R2A

COSMIC (genes):PPP2R2A PPP2R2A

CTD Gene:5520 PPP2R2A

dbSNP Gene:5520 PPP2R2A

ENSEMBL:ENSG00000221914 PPP2R2A

HGNC:9304 PPP2R2A

KEGG Gene (Homo sapiens):5520 PPP2R2A

Monarch:5520 PPP2R2A

NCBI Gene:5520 PPP2R2A

OMIM:604941 PPP2R2A

UCSC:P63151 PPP2R2A

Reference Transcript

Other Identifiers

0000670397

11756714_a_at

1383_at

202313_at

228013_at

3090938

3090939

3090940

3090941

3090943

3090944

3090956

3090961

3090964

3090967

3090972

3090973

3090975

3090982

3090983

3090988

3090989

3090990

3090991

3090992

3090993

3090994

3487899

41167_at

46187_at

5520

8145440

82421_i_at

82422_r_at

A_14_P123050

A_23_P123539

A_24_P346644

GE58038

GO:0000086

GO:0000159

GO:0000184

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006470

GO:0007049

GO:0007084

GO:0008092

GO:0008150

GO:0009056

GO:0019888

GO:0019899

GO:0030234

GO:0032991

GO:0034641

GO:0034655

GO:0043226

GO:0043278

GO:0043666

GO:0044877

GO:0045202

GO:0048156

GO:0051721

GO:0061024

GO:0070262

GO:0098978

Hs.61696.0.A1_3p_at

ILMN_1788961

M64929_at

PH_hs_0028631

g4506018_3p_at

Participant Of

hasComponent

PP2A (Aalpha:B55alpha:Calpha) [cytosol]

Other forms of this molecule

PPP2R2A [nucleoplasm]

Inferred To

tws [cytosol] (Drosophila melanogaster)

Homologues of PPP2R2A [cytosol] (Dictyostelium discoideum)

phr2aB [cytosol] (Dictyostelium discoideum)

CDC55 [cytosol] (Saccharomyces cerevisiae)

atrx [cytosol] (Xenopus tropicalis)

pab1 [cytosol] (Schizosaccharomyces pombe)

sur-6 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PPP2R2A [cytosol] (Bos taurus)

Ghost homologue of PPP2R2A [cytosol] (Plasmodium falciparum)

Ghost homologue of PPP2R2A [cytosol] (Sus scrofa)

PPP2R2A [cytosol] (Canis familiaris)

PPP2R2A [cytosol] (Dictyostelium discoideum)

PPP2R2A [cytosol] (Gallus gallus)

Ppp2r2a [cytosol] (Mus musculus)

Ppp2r2a [cytosol] (Rattus norvegicus)

ppp2r2ab [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001171062.1, NP_002708.1

OpenTargets

ENSG00000221914

GeneCards

P63151

HPA

ENSG00000221914-PPP2R2A

ZINC target

P63151

Ensembl

ENSP00000370113, ENST00000380737, ENST00000315985, ENSP00000325074, ENSG00000221914

PRO

P63151

PDB

3DW8

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.641	4
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.462	2
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	2
UniProt:Q8N163 CCAR2	2	p-T454-DBC1 [nucleoplasm] (R-HSA-3371569) DBC1 [nucleoplasm] (R-HSA-3371479)	0.462	2
UniProt:P42285 MTREX	1	SKIV2L2 [nucleoplasm] (R-HSA-6791189)	0.462	2

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