Reactome | PPP2R2A [cytosol]

PPP2R2A [cytosol]

Stable Identifier

R-HSA-377253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-regulatory subunit B55 alpha isoform

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 binds PP2A (Homo sapiens)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates BANF1 (Homo sapiens)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
        
        PPP2R2A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63151 PPP2R2A

Gene Names

PPP2R2A

Chain

initiator methionine:1, chain:2-447

Reference Genes

BioGPS Gene:5520 PPP2R2A

COSMIC (genes):PPP2R2A PPP2R2A

CTD Gene:5520 PPP2R2A

dbSNP Gene:5520 PPP2R2A

ENSEMBL:ENSG00000221914 PPP2R2A

ENSEMBL:ENSG00000221914.11 PPP2R2A

HGNC:9304 PPP2R2A

KEGG Gene (Homo sapiens):5520 PPP2R2A

Monarch:5520 PPP2R2A

NCBI Gene:5520 PPP2R2A

OMIM:604941 PPP2R2A

UCSC:P63151 PPP2R2A

Reference Transcript

Other Identifiers

11756714_a_at

1383_at

202313_PM_at

202313_at

228013_PM_at

228013_at

3090938

3090939

3090940

3090941

3090943

3090944

3090956

3090961

3090964

3090967

3090972

3090973

3090975

3090982

3090983

3090988

3090989

3090990

3090991

3090992

3090993

3090994

3487899

41167_at

46187_at

5520

8145440

82421_i_at

82422_r_at

A_14_P123050

A_23_P123539

A_24_P346644

GE58038

GO:0000159

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006470

GO:0019888

GO:0036211

GO:0043226

GO:0043278

GO:0045202

GO:0098772

GO:0098978

HMNXSV003024886

Hs.61696.0.A1_3p_at

ILMN_1788961

M64929_at

PH_hs_0028631

g4506018_3p_at

p33838

Participates

as a component of

PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2R2A [nucleoplasm]

Inferred To

tws [cytosol] (Drosophila melanogaster)

phr2aB [cytosol] (Dictyostelium discoideum)

CDC55 [cytosol] (Saccharomyces cerevisiae)

pab1 [cytosol] (Schizosaccharomyces pombe)

sur-6 [cytosol] (Caenorhabditis elegans)

ppp2r2a [cytosol] (Xenopus tropicalis)

Ghost homologue of PPP2R2A [cytosol] (Plasmodium falciparum)

MDS026 [cytosol] (Danio rerio)

PPP2R2A [cytosol] (Bos taurus)

PPP2R2A [cytosol] (Canis familiaris)

PPP2R2A [cytosol] (Gallus gallus)

PPP2R2A [cytosol] (Sus scrofa)

Ppp2r2a [cytosol] (Mus musculus)

Ppp2r2a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002708.1, NP_001171062.1

OpenTargets

ENSG00000221914

GeneCards

P63151

HPA

ENSG00000221914-PPP2R2A

Ensembl

ENST00000315985, ENSG00000221914, ENSP00000325074, ENST00000380737, ENSP00000370113

ZINC target

P63151

PRO

P63151

Pharos - Targets

P63151

PDB

3DW8

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.641	4
UniProt:Q99958 FOXC2	1	FOXC2 [nucleoplasm] (R-HSA-3927898)	0.564	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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