Autophosphorylation of SRC

Stable Identifier
R-HSA-377640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Clustering of Integrin alphaIIb beta3 complexes results in the trans auto-phosphorylation of SRC tyrosine residue 419 (often referred to as 418 in the literature, as the initiating methionine is cleaved in the mature peptide) in SRC's kinase activation loop.

Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!