Autophosphorylation of SRC

Stable Identifier
R-HSA-377640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Autophosphorylation of SRC
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Clustering of Integrin alphaIIb beta3 complexes results in the trans auto-phosphorylation of SRC tyrosine residue 419 (often referred to as 418 in the literature, as the initiating methionine is cleaved in the mature peptide) in SRC's kinase activation loop.

Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
SRC-1 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Autophosphorylation of SRC (Caenorhabditis elegans)
Autophosphorylation of SRC (Canis familiaris)
Autophosphorylation of SRC (Danio rerio)
Autophosphorylation of SRC (Mus musculus)
Autophosphorylation of SRC (Rattus norvegicus)
Autophosphorylation of SRC (Xenopus tropicalis)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-09-15)