Dephosphorylation of inactive SRC by PTPB1

Stable Identifier
R-HSA-377643
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity.

Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
16115959 PTP-1B is an essential positive regulator of platelet integrin signaling

Arias-Salgado, EG, Haj, F, Dubois, C, Moran, B, Kasirer-Friede, A, Furie, BC, Furie, B, Neel, BG, Shattil, SJ

J Cell Biol 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created