Release of CSK from SRC

Stable Identifier
R-HSA-377644
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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CSK bound to integrin alphaIIb beta3 negatively regulates SRC by phosphorylating the Tyr-530. Platelet adhesion to fibrinogen causes the disassociation of CSK from alphaIIb beta3 complex.

Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
1722201 CSK: a protein-tyrosine kinase involved in regulation of src family kinases

Okada, M, Nada, S, Yamanashi, Y, Yamamoto, T, Nakagawa, H

J Biol Chem 1991
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