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CCS [mitochondrial intermembrane space]
Stable Identifier
R-HSA-3777060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
Copper chaperone for superoxide dismutase, CCS_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)
CCS dimer [mitochondrial intermembrane space] (Homo sapiens)
CCS:Zn2+:Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
CCS [mitochondrial intermembrane space] (Homo sapiens)
CCS:SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
CCS:Zn2+:2Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
CCS [mitochondrial intermembrane space] (Homo sapiens)
SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)
CCS:Cu1+ dimer [mitochondrial intermembrane space] (Homo sapiens)
CCS:Zn2+:2Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
CCS [mitochondrial intermembrane space] (Homo sapiens)
CCS:SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
CCS:Zn2+:2Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
CCS [mitochondrial intermembrane space] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14618 CCS
Gene Names
CCS
Chain
chain:1-274
Reference Genes
BioGPS Gene:9973 CCS
COSMIC (genes):CCS CCS
CTD Gene:9973 CCS
dbSNP Gene:9973 CCS
ENSEMBL:ENSG00000173992 CCS
HGNC:1613 CCS
KEGG Gene (Homo sapiens):9973 CCS
Monarch:9973 CCS
NCBI Gene:9973 CCS
OMIM:603864 CCS
UCSC:O14618 CCS
Reference Transcript
RefSeq:NM_005125.1 CCS
Other Identifiers
0006510279
11720675_a_at
11720676_s_at
16727524
203522_at
3336353
3336354
3336355
3336357
3336359
3336361
3336363
3336364
3336365
3336366
36068_at
58948_at
7941685
9973
A_14_P114545
A_23_P127475
GE54047
GO:0003674
GO:0004784
GO:0005507
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006801
GO:0006810
GO:0006950
GO:0008150
GO:0015035
GO:0015680
GO:0016491
GO:0019430
GO:0030001
GO:0034599
GO:0043167
GO:0043226
GO:0045296
GO:0046872
GO:0051353
GO:0051604
GO:0055114
HMNXSV003029983
ILMN_1747384
ILMN_1766797
ILMN_2290998
PH_hs_0000512
TC11000672.hg
g4826664_3p_at
Participates
as a component of
CCS:Zn2+:2Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
CCS:Zn2+:Cu1+ [mitochondrial intermembrane space] (Homo sapiens)
Other forms of this molecule
CCS [cytosol]
Inferred From
Ccs [mitochondrial intermembrane space]
(Mus musculus)
CCS1 [mitochondrial intermembrane space]
(Saccharomyces cerevisiae)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 141 and 227
Coordinate
141
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_005116.1
OpenTargets
ENSG00000173992
GeneCards
O14618
HPA
ENSG00000173992-CCS
Ensembl
ENSG00000173992
,
ENSP00000436318
,
ENST00000533244
PRO
O14618
Orphanet
28866
PDB
6FN8
,
1DO5
,
6FP6
,
2RSQ
,
6FOL
,
2CRL
,
6FON
HMDB Protein
HMDBP08238
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [extracellular region]
(R-HSA-350705)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
0.744
4
UniProt:P98170 XIAP
3
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
XIAP [cytosol]
(R-HSA-50849)
0.499
2
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