Reactome | SOD1 [mitochondrial intermembrane space]

SOD1 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-3777082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

Superoxide dismutase [Cu-Zn] ecNumber1.15.1.1/ecNumber, SODC_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P0CG47

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of SOD1 (Homo sapiens)
        
        SOD1 [mitochondrial intermembrane space] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21393238	Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation He, C, Murthy, S, McCormick, ML, Spitz, DR, Ryan, AJ, Carter, AB	J. Biol. Chem.	2011
11886899	Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS Higgins, CM, Jung, C, Ding, H, Xu, Z	J. Neurosci.	2002

External Reference Information

External Reference

UniProt:P00441 SOD1

Gene Names

SOD1

Chain

initiator methionine:1, chain:2-154

Reference Genes

BioGPS Gene:6647 SOD1

COSMIC (genes):SOD1 SOD1

CTD Gene:6647 SOD1

dbSNP Gene:6647 SOD1

ENSEMBL:ENSG00000142168 SOD1

HGNC:11179 SOD1

KEGG Gene (Homo sapiens):6647 SOD1

Monarch:6647 SOD1

NCBI Gene:6647 SOD1

OMIM:147450 SOD1

Reference Transcript

RefSeq:NM_000454.4 SOD1

Other Identifiers

0000130315

11716935_a_at

11756351_x_at

11757619_x_at

16922102

200642_at

36620_at

3917873

3917874

3917882

3917888

3917890

3917892

3917893

3917894

3917895

3917896

3917897

3917911

6647

8068168

A_14_P105406

A_23_P154840

A_24_P151464

GE79683

GO:0000003

GO:0000187

GO:0000302

GO:0000303

GO:0000902

GO:0001541

GO:0001819

GO:0001890

GO:0001895

GO:0001975

GO:0002262

GO:0002376

GO:0002576

GO:0003013

GO:0003674

GO:0004784

GO:0005507

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005758

GO:0005759

GO:0005764

GO:0005773

GO:0005777

GO:0005829

GO:0005886

GO:0006464

GO:0006629

GO:0006749

GO:0006790

GO:0006801

GO:0006810

GO:0006879

GO:0006950

GO:0006979

GO:0007009

GO:0007010

GO:0007165

GO:0007283

GO:0007566

GO:0007568

GO:0007569

GO:0007605

GO:0007626

GO:0008089

GO:0008090

GO:0008150

GO:0008217

GO:0008219

GO:0008270

GO:0009058

GO:0009408

GO:0009790

GO:0010033

GO:0016192

GO:0016209

GO:0016491

GO:0019226

GO:0019430

GO:0019899

GO:0030141

GO:0030154

GO:0030346

GO:0030705

GO:0031045

GO:0031267

GO:0031410

GO:0031667

GO:0032287

GO:0032839

GO:0032930

GO:0032991

GO:0033081

GO:0034465

GO:0034599

GO:0034641

GO:0035722

GO:0035865

GO:0040007

GO:0040014

GO:0042493

GO:0042542

GO:0042554

GO:0042592

GO:0042802

GO:0043005

GO:0043025

GO:0043065

GO:0043066

GO:0043085

GO:0043087

GO:0043167

GO:0043226

GO:0043524

GO:0044281

GO:0045471

GO:0045541

GO:0045859

GO:0046620

GO:0046677

GO:0046688

GO:0046716

GO:0046872

GO:0048538

GO:0048678

GO:0048856

GO:0050665

GO:0050728

GO:0050766

GO:0050877

GO:0051087

GO:0051881

GO:0055114

GO:0060047

GO:0060052

GO:0060087

GO:0060088

GO:0061024

GO:0070062

GO:0071276

GO:0071318

GO:0072593

GO:0097332

GO:1902177

GO:1904115

HMNXSV003042786

ILMN_1662438

PH_hs_0025933

TC21000111.hg

X02317_at

g4507148_3p_at

Participates

as an output of

Expression of SOD1 (Homo sapiens)

as a component of

SOD1:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

SOD1 [extracellular region]

2xHC-SOD1 [cytosol]

SOD1 [cytosol]

2xHC-SOD1 [mitochondrial intermembrane space]

Cross References

RefSeq

NP_000445.1

Target Pathogen

5b354852be737e166372ea0c

OpenTargets

ENSG00000142168

GeneCards

P00441

HPA

ENSG00000142168-SOD1

Ensembl

ENSP00000270142, ENST00000270142, ENSG00000142168

ZINC target

P00441

PRO

P00441

Orphanet

15536

HMDB Protein

HMDBP02053

PDB

5O40, 1UXL, 4NIP, 4A7U, 5O3Y, 3GZQ, 3K91, 3GQF, 4A7T, 1HL5, 1OEZ, 2AF2, 2WZ0, 2ZKW, 4BCY, 5K02, 2ZKX, 2XJK, 1OZU, 4FF9, 6FLH, 2LU5, 1P1V, 1SOS, 4A7G, 3HFF, 6DTK, 6FOL, 2GBV, 3CQQ, 6SPH, 6Z4O, 6SPI, 3H2P, 6FON, 2NNX, 6A9O, 3ECU, 5U9M, 3LTV, 5J0C, 3KH3, 5WMJ, 6Z4K, 5J0F, 6Z4J, 2WKO, 2ZKY, 2WZ5, 5YTO, 2WZ6, 6FFK, 1PU0, 2NAM, 1L3N, 3QQD, 4BD4, 2V0A, 2C9U, 1PTZ, 2C9V, 2VR6, 1MFM, 6Z4G, 4B3E, 1KMG, 4OH2, 4NIO, 5WOR, 1SPD, 1RK7, 6Z3V, 4NIN, 1OZT, 2MP3, 2WYT, 4A7V, 5DLI, 5IIW, 3KH4, 2GBT, 2GBU, 3CQP, 3T5W, 6SPJ, 6FP6, 3H2Q, 5YUL, 4MCN, 4A7S, 3GZP, 4MCM, 1HL4, 3GZO, 4A7Q, 2VR7, 5J0G, 2R27, 2VR8, 6Z4M, 6FOI, 6SPA, 6Z4L, 1BA9, 6B79, 5YTU, 6SPK, 3ECW, 4SOD, 3ECV, 1UXM, 4XCR, 2C9S, 2XJL, 6Z4I, 1AZV, 2WYZ, 1FUN, 6Z4H, 1N18, 3RE0, 4BCZ, 1DSW, 3GTV, 1N19, 5J07

Interactors (89)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [extracellular region] (R-HSA-350705) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082)	0.977	21
UniProt:O14618 CCS	2	CCS [mitochondrial intermembrane space] (R-HSA-3777060) CCS [cytosol] (R-HSA-3299714)	0.744	4
UniProt:P20029 Hspa5	6	78 kDa glucose-regulated protein precursor [endoplasmic reticulum lumen] (R-MMU-351326) 78 kDa glucose-regulated protein precursor [extracellular region] (R-MMU-351324) Hspa5 [endoplasmic reticulum membrane] (R-MMU-351315) Hspa5 [cytosol] (R-MMU-5252115) Hspa5 [nucleoplasm] (R-MMU-5252042) Hspa5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-985498)	0.688	7
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.666	5
UniProt:P26339	2	Chga [extracellular region] (R-MMU-6808524) Chga [extracellular region] (R-MMU-6808568)	0.625	5
UniProt:P30044 PRDX5			0.612	10
UniProt:P16014	2	Chgb [endoplasmic reticulum lumen] (R-MMU-8956734) phospho-Chgb [endoplasmic reticulum lumen] (R-MMU-8956928)	0.602	6
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.564	3
IntAct:EBI-25835814 CCSB			0.556	3
UniProt:Q96MF2 STAC3			0.556	3
UniProt:Q8WW76 Q8WW76			0.556	3
UniProt:Q3SY56 SP6			0.556	3
UniProt:P07951-2 TPM2			0.556	3
UniProt:Q9H3N1 TMX1			0.556	3
IntAct:EBI-25850770 CCSB			0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:Q08209-2 PPP3CA			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q0P5N6 ARL16			0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.556	3
UniProt:Q15554-4 Q155544			0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:Q9GZS3 WDR61	2	WDR61 [nucleoplasm] (R-HSA-8866696) WDR61 [cytosol] (R-HSA-8931534)	0.556	3
IntAct:EBI-25934407 CCSB			0.556	3
UniProt:Q2NKQ1-4 SGSM1			0.556	3
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:Q9NV58 RNF19A	1	RNF19A [cytosol] (R-HSA-8850909)	0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:P13928 ANXA8			0.556	3
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.556	3
UniProt:P53672 CRBA2			0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:Q15046 KARS1	2	KARS [cytosol] (R-HSA-379568) KARS [mitochondrial matrix] (R-HSA-379617)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:P43686-2 P436862			0.556	3
UniProt:Q8TC29 ENKUR			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:P80217-2 IFI35			0.556	3
UniProt:Q8WVV9-3 Q8WVV93			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
UniProt:O14713 ITBP1			0.556	3
IntAct:EBI-25849442 CCSB			0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.556	3
UniProt:Q8TDB4 HUMMR			0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:F2Z2M7 F2Z2M7			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
IntAct:EBI-25934389 CCSB			0.556	3
UniProt:P60896 SEM1	2	SHFM1 [cytosol] (R-HSA-8866674) SHFM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:O95789-4 ZMYM6			0.556	3
UniProt:Q8N5S9-2 Q8N5S92			0.556	3
UniProt:Q9Y4H4 GPSM3	1	GPSM3 [cytosol] (R-HSA-8949486)	0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q9NVX7-2 Q9NVX72			0.556	3
UniProt:P62879 GNB2	4	Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335) Partially folded GNB2 [cytosol] (R-HSA-8850536) GNB2 [cytosol] (R-HSA-6814421)	0.556	3
UniProt:Q2QGD7 ZXDC			0.556	3
IntAct:EBI-25888984 CCSB			0.556	3
UniProt:P02671-2 FGA			0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:Q96NC0 ZMAT2			0.556	3
UniProt:P07437 TUBB	3	TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P0CG47 UBB	109	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(153-228) [late endosome lumen] (R-HSA-9660014) UBB(77-152) [late endosome lumen] (R-HSA-9660021) UBB(1-76) [late endosome lumen] (R-HSA-9660017) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) UBB(77-152) [lysosomal lumen] (R-HSA-9660011) UBB(1-76) [lysosomal lumen] (R-HSA-9660024) UBB(153-228) [lysosomal lumen] (R-HSA-9660025) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.556	3
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.556	3
UniProt:P98082 DAB2	3	DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.556	3
UniProt:P02748 C9	1	C9(22-559) [extracellular region] (R-HSA-173717)	0.556	3
UniProt:P07686 HEXB	10	HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(315-556) [lysosomal lumen] (R-HSA-1605605) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843)	0.527	2
UniProt:Q99497 PARK7	7	PARK7 [nucleoplasm] (R-HSA-3900141) SUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.527	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [cilium] (R-HSA-5624862) DYNC2LI1 [ciliary tip] (R-HSA-5625333)	0.499	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.499	3
UniProt:Q6DN90 IQEC1			0.471	2

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