Reactome | SOD1 [mitochondrial intermembrane space]

SOD1 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-3777082

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

Superoxide dismutase [Cu-Zn] ecNumber1.15.1.1/ecNumber, SODC_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9NVX7-2 Q9NVX72

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of SOD1 (Homo sapiens)
        
        SOD1 [mitochondrial intermembrane space] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
11886899	Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS Higgins, CM, Jung, C, Ding, H, Xu, Z	J. Neurosci.	2002
21393238	Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation He, C, Murthy, S, McCormick, ML, Spitz, DR, Ryan, AJ, Carter, AB	J. Biol. Chem.	2011

External Reference Information

External Reference

UniProt:P00441 SOD1

Gene Names

SOD1

Chain

initiator methionine:1, chain:2-154

Reference Genes

BioGPS Gene:6647 SOD1

COSMIC (genes):SOD1 SOD1

CTD Gene:6647 SOD1

dbSNP Gene:6647 SOD1

ENSEMBL:ENSG00000142168 SOD1

HGNC:11179 SOD1

KEGG:hsa:6647 SOD1

Monarch:6647 SOD1

NCBI Gene:6647 SOD1

OMIM:147450 SOD1

UCSC:P00441 SOD1

Reference Transcript

RefSeq:NM_000454.5 SOD1

Other Identifiers

11716935_a_at

11756351_x_at

11757619_x_at

16922102

200642_PM_at

200642_at

36620_at

3917873

3917874

3917875

3917876

3917878

3917882

3917888

3917890

3917891

3917892

3917893

3917894

3917895

3917896

3917897

3917911

6647

8068168

A_14_P105406

A_23_P154840

A_24_P151464

GE79683

GO:0000302

GO:0000303

GO:0001541

GO:0001819

GO:0001890

GO:0001895

GO:0001975

GO:0002262

GO:0002376

GO:0003012

GO:0003013

GO:0004784

GO:0005507

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005758

GO:0005759

GO:0005764

GO:0005777

GO:0005829

GO:0005886

GO:0006575

GO:0006749

GO:0006790

GO:0006801

GO:0006879

GO:0006915

GO:0006979

GO:0007010

GO:0007018

GO:0007283

GO:0007566

GO:0007605

GO:0007626

GO:0008089

GO:0008090

GO:0008217

GO:0008270

GO:0008340

GO:0009408

GO:0009410

GO:0010467

GO:0012501

GO:0016209

GO:0016491

GO:0019226

GO:0019228

GO:0019430

GO:0019899

GO:0022414

GO:0030141

GO:0030346

GO:0031045

GO:0031267

GO:0031410

GO:0031667

GO:0032287

GO:0032839

GO:0032930

GO:0032991

GO:0033081

GO:0034465

GO:0034599

GO:0035234

GO:0035865

GO:0040014

GO:0042542

GO:0042554

GO:0042802

GO:0042803

GO:0043025

GO:0043065

GO:0043066

GO:0043087

GO:0043410

GO:0043524

GO:0045471

GO:0046620

GO:0046688

GO:0046716

GO:0046872

GO:0048538

GO:0048678

GO:0048856

GO:0050665

GO:0050728

GO:0050766

GO:0050877

GO:0051087

GO:0051093

GO:0051881

GO:0060047

GO:0060052

GO:0060087

GO:0060088

GO:0070062

GO:0071276

GO:0071318

GO:0072593

GO:0097332

GO:0098754

GO:0098869

GO:0099610

GO:1902177

GO:1904115

GO:2000242

HMNXSV003042786

ILMN_1662438

PH_hs_0025933

TC21000111.hg

X02317_at

g4507148_3p_at

Participates

as an output of

Expression of SOD1 (Homo sapiens)

as a component of

SOD1:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

2xHC-SOD1 [cytosol]

SOD1 [cytosol]

2xHC-SOD1 [mitochondrial intermembrane space]

SOD1 [extracellular region]

Cross References

RefSeq

NP_000445.1

OpenTargets

ENSG00000142168

ENSEMBL

ENSG00000142168, ENSP00000270142, ENST00000270142

ZINC - Substances

SODC_HUMAN

ZINC target

P00441

PRO

P00441

GlyGen

P00441

PDB

1HL4, 3GZO, 4XCR, 8GSQ, 4FF9, 1DSW, 5YTO, 6Z4H, 4NIP, 6SPH, 8K3L, 4BCZ, 4NIO, 2VR8, 4A7S, 2GBT, 3K91, 2VR7, 8Q6M, 6FOI, 2C9S, 6Z4O, 2NNX, 6Z4M, 5YUL, 8CCX, 1HL5, 6Z3V, 7FB9, 1AZV, 4A7V, 9JBO, 6SPA, 7NXX, 2WZ0, 1MFM, 3HFF, 5U9M, 2XJK, 6FOL, 8YAT, 2R27, 4OH2, 2ZKW, 7VZF, 1BA9, 4NIN, 3RE0, 6A9O, 5J0F, 3KH3, 7T8H, 3H2P, 6SPK, 8IHU, 2WKO, 5O40, 4B3E, 1SPD, 2MP3, 1N19, 2GBU, 5J07, 5YTU, 6Z4K, 7T8E, 6FLH, 6SPJ, 3ECV, 2NAM, 1KMG, 9IYK, 3T5W, 4MCM, 1OZU, 1UXM, 7CJW, 5IIW, 3GZP, 6FP6, 6FON, 2ZKX, 7XX3, 4MCN, 5J0G, 3ECU, 4A7T, 3H2Q, 2WYT, 3LTV, 3GQF, 8IHV, 1RK7, 1N18, 6Z4L, 2WYZ, 2C9V, 1FUN, 2V0A, 2GBV, 6Z4J, 8K3A, 7T8F, 9JBP, 6SPI, 5DLI, 8YD3, 1UXL, 3GTV, 1L3N, 5K02, 3GZQ, 6B79, 3QQD, 2ZKY, 1SOS, 1OEZ, 7T8G, 3KH4, 6Z4I, 6DTK, 2WZ6, 6FFK, 2WZ5, 4BCY, 7FB6, 5J0C, 5WMJ, 2VR6, 3CQQ, 8K33, 4BD4, 4A7Q, 2C9U, 6Z4G, 2LU5, 5O3Y, 3ECW, 3CQP, 4A7U, 1PTZ, 4A7G, 1OZT, 2AF2, 1PU0, 1P1V, 7CJV, 2XJL, 5WOR

GeneCards

SOD1

HPA

ENSG00000142168-SOD1

Pharos - Targets

P00441

Orphanet

SOD1

HMDB Protein

HMDBP02053

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705)	0.978	22
UniProt:O14618 CCS	2	CCS [mitochondrial intermembrane space] (R-HSA-3777060) CCS [cytosol] (R-HSA-3299714)	0.832	7
UniProt:P20029 Hspa5	7	78 kDa glucose-regulated protein precursor [extracellular region] (R-MMU-351324) 78 kDa glucose-regulated protein precursor [endoplasmic reticulum lumen] (R-MMU-351326) Hspa5 [cytosol] (R-MMU-5252115) Hspa5 [nucleoplasm] (R-MMU-5252042) Hspa5 [endoplasmic reticulum lumen] (R-MMU-387190) Hspa5 [endoplasmic reticulum membrane] (R-MMU-351315) Hspa5 [lumenal side of endoplasmic reticulum membrane] (R-MMU-985498)	0.688	7
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.666	5
UniProt:P26339	2	Chga [extracellular region] (R-MMU-6808568) Chga [extracellular region] (R-MMU-6808524)	0.625	5
UniProt:P30044 PRDX5			0.612	10
UniProt:P16014	2	phospho-Chgb [endoplasmic reticulum lumen] (R-MMU-8956928) Chgb [endoplasmic reticulum lumen] (R-MMU-8956734)	0.602	6
UniProt:Q9BXK5 B2L13			0.589	2
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.567	9
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.564	3
IntAct:EBI-25835814 CCSB			0.556	3
UniProt:Q96MF2 STAC3			0.556	3
UniProt:Q8WW76 Q8WW76			0.556	3
UniProt:Q3SY56 SP6			0.556	3
UniProt:P07951-2 TPM2			0.556	3
UniProt:Q9H3N1 TMX1			0.556	3
IntAct:EBI-25850770 CCSB			0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:Q08209-2 PPP3CA			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q0P5N6 ARL16			0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.556	3
UniProt:Q15554-4 Q155544			0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:Q2NKQ1-4 SGSM1			0.556	3
IntAct:EBI-25934407 CCSB			0.556	3
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:Q9NV58 RNF19A	1	RNF19A [cytosol] (R-HSA-8850909)	0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:P13928 ANXA8			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:P08865 RPSA	3	RPSA [cytosol] (R-HSA-72389) RPSA [plasma membrane] (R-HSA-9922472) RPSA [nucleoplasm] (R-HSA-6798722)	0.556	3
UniProt:P53672 CRBA2			0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:Q15046 KARS1	4	KARS [cytosol] (R-HSA-379568) p-S207 KARS [cytosol] (R-HSA-9825686) p-S207 KARS [nucleoplasm] (R-HSA-9825687) KARS [mitochondrial matrix] (R-HSA-379617)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:P98082 DAB2	3	DAB2 [plasma membrane] (R-HSA-2980808) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456)	0.556	3
UniProt:P43686-2 P436862			0.556	3
UniProt:Q8TC29 ENKUR			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:P80217-2 IFI35			0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q8WVV9-3 Q8WVV93			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
UniProt:O14713 ITBP1			0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:P02671-2 FGA			0.556	3
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.556	3
IntAct:EBI-25888984 CCSB			0.556	3
UniProt:Q2QGD7 ZXDC			0.556	3
UniProt:P02748 C9	1	C9(22-559) [extracellular region] (R-HSA-173717)	0.556	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q9NVX7-2 Q9NVX72			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:Q9Y4H4 GPSM3	1	GPSM3 [cytosol] (R-HSA-8949486)	0.556	3
UniProt:Q8N5S9-2 Q8N5S92			0.556	3
UniProt:O95789-4 ZMYM6			0.556	3
IntAct:EBI-25934389 CCSB			0.556	3
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:F2Z2M7 F2Z2M7			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:Q8TDB4 HUMMR			0.556	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
IntAct:EBI-25849442 CCSB			0.556	3
UniProt:P07686 HEXB	11	HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(50-107) [lysosomal lumen] (R-HSA-9842398) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(316-556) [lysosomal lumen] (R-HSA-1605605)	0.527	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.527	2
UniProt:Q9BQE5 APOL2			0.527	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.499	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.499	3
UniProt:Q6DN90 IQEC1			0.471	2

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