SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)

Stable Identifier
R-HSA-3777112
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A portion of SOD1 is located in the mitochondrial intermembrane space (IMS) where it catalyzes the formation of oxygen (O2) and hydrogen peroxide (H2O2) from superoxide (O2.-) (He et al. 2011, Higgins et al. 2002, inferred from rat in Okado-Matsumoto and Fridovich 2001).

Literature References
PubMed ID Title Journal Year
11886899 Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Higgins, CM, Jung, C, Ding, H, Xu, Z

J. Neurosci. 2002
11507097 Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

Okado-Matsumoto, A, Fridovich, I

J. Biol. Chem. 2001
21393238 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

He, C, Murthy, S, McCormick, ML, Spitz, DR, Ryan, AJ, Carter, AB

J. Biol. Chem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed