CCS transfers Cu to SOD1 (mitochondrial)

Stable Identifier
R-HSA-3780979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from the cytosolic reaction and from the mitochondrial reaction in mouse, Copper chaperone of superoxide dismutase (CCS) transfers a copper(I) atom to a SOD1 monomer that already contains a Zn atom. After initial heterodimerization between SOD1 and CCS, the copper atom is transferred, intramolecular cysteine disulfide bonds are formed in SOD1, and SOD1 dimerizes.

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