Reactome | MRN complex binds DNA double strand breaks

MRN complex binds DNA double strand breaks

Stable Identifier

R-HSA-3785768

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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MRN complex binds DNA double strand breaks

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The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15790808	ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Lee, JH, Paull, TT	Science	2005
15458641	Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break Shroff, R, Arbel-Eden, A, Pilch, D, Ira, G, Bonner, WM, Petrini, JH, Haber, JE, Lichten, M	Curr. Biol.	2004
15369670	Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins Lisby, M, Barlow, JH, Burgess, RC, Rothstein, R	Cell	2004