MRN complex binds DNA double strand breaks

Stable Identifier
R-HSA-3785768
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).

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Orthologous Events
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