Reactome | MRN complex binds DNA double strand breaks

MRN complex binds DNA double strand breaks

Stable Identifier

R-HSA-3785768

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Summation

The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).

Literature References

15790808	ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex	Science	2005
15458641	Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break	Curr. Biol.	2004
15369670	Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins	Cell	2004

Participants

input

DNA double-strand break ends [nucleoplasm]
MRN [nucleoplasm] (Homo sapiens)

output

DNA DSBs:MRN [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

DNA Damage/Telomere Stress Induced Senescence
Sensing of DNA Double Strand Breaks

Orthologous Events

MRN complex binds DNA double strand breaks (Arabidopsis thaliana)
MRN complex binds DNA double strand breaks (Danio rerio)
MRN complex binds DNA double strand breaks (Drosophila melanogaster)
MRN complex binds DNA double strand breaks (Gallus gallus)
MRN complex binds DNA double strand breaks (Mus musculus)
MRN complex binds DNA double strand breaks (Oryza sativa)
MRN complex binds DNA double strand breaks (Rattus norvegicus)
MRN complex binds DNA double strand breaks (Taeniopygia guttata)
MRN complex binds DNA double strand breaks (Xenopus tropicalis)