The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).
Lee, JH, Paull, TT
Shroff, R, Arbel-Eden, A, Pilch, D, Ira, G, Bonner, WM, Petrini, JH, Haber, JE, Lichten, M
Lisby, M, Barlow, JH, Burgess, RC, Rothstein, R
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