MRN complex binds DNA double strand breaks

Stable Identifier
R-HSA-3785768
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).

Literature References
PubMed ID Title Journal Year
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Lee, JH, Paull, TT

Science 2005
15458641 Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

Shroff, R, Arbel-Eden, A, Pilch, D, Ira, G, Bonner, WM, Petrini, JH, Haber, JE, Lichten, M

Curr. Biol. 2004
15369670 Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

Lisby, M, Barlow, JH, Burgess, RC, Rothstein, R

Cell 2004
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Orthologous Events
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Borowiec, JA  (2015-06-12)