Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDKN1A gene [nucleoplasm]
Stable Identifier
R-HSA-3786256
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p21 gene, WAF1 gene, CIP1 gene
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Transcriptional activation of p53 responsive genes (Homo sapiens)
Transcriptional activation of cell cycle inhibitor p21 (Homo sapiens)
TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
EP400 binds CDKN1A promoter (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
SAHF formation (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TP53 binds the CDKN1A promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
MITF-M dimer binds the CDKN1A gene (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
MITF-M dimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
MITF-M-dependent CDKN1A expression (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
MITF-M dimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5 binds the CDKN1A gene (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5 binds the CDKN1A gene (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK- and JUN-dependent CDKN1A gene repression (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,FOXO4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,FOXO4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
RUNX2 binds CDKN1A gene promoter (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates CDKN1A transcription (Homo sapiens)
CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2A homodimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2A homodimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)
STAT3-upregulated genes for cytosolic proteins [nucleoplasm] (Homo sapiens)
CDKN1A gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000124762 CDKN1A
Gene Names
CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Participates
as a member of
STAT3-upregulated genes for cytosolic proteins [nucleoplasm] (Homo sapiens)
as an input of
NPM1-ALK- and JUN-dependent CDKN1A gene repression (Homo sapiens)
p-STAT5 binds the CDKN1A gene (Homo sapiens)
FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
MITF-M dimer binds the CDKN1A gene (Homo sapiens)
MITF-M-dependent CDKN1A expression (Homo sapiens)
RUNX2 binds CDKN1A gene promoter (Homo sapiens)
CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)
CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)
CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)
The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)
TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
TP53 binds the CDKN1A promoter (Homo sapiens)
Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)
FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)
FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)
CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)
TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)
as a component of
p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)
MITF-M dimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm] (Homo sapiens)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2A homodimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,FOXO4:CDKN1A gene [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of CDKN1A gene [nucleoplasm]
(Bos taurus)
Ghost homologue of CDKN1A gene [nucleoplasm]
(Canis familiaris)
Ghost homologue of CDKN1A gene [nucleoplasm]
(Mus musculus)
Ghost homologue of CDKN1A gene [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CDKN1A gene [nucleoplasm]
(Sus scrofa)
Ghost homologue of CDKN1A gene [nucleoplasm]
(Xenopus tropicalis)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
