Fibronectin degradation by ADAM8

Stable Identifier
R-HSA-3788061
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ADAM8 can cleave fibronectin in human cartilage extracts at Ala271/Val272, within a linker region between the fifth and sixth type I domains, producing ?30-kd and ?50–85-kd fragments with distinctive neoepitopes VRAA271 and 272VYQP that are associated with osteoarthritis (Zack et al. 2006, 2009).

Literature References
PubMed ID Title Journal Year
19714641 ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271)

Zack, MD, Malfait, AM, Skepner, AP, Yates, MP, Griggs, DW, Hall, T, Hills, RL, Alston, JT, Nemirovskiy, OV, Radabaugh, MR, Leone, JW, Arner, EC, Tortorella, MD

Arthritis Rheum. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of ADAM8 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!