Cdh1:APC/C complex binds EHMT1:EHMT2

Stable Identifier
R-HSA-3788725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cdh1 (FZR1) is able to bind both G9a (EHMT2) and GLP (EHMT1) (Takahashi et al. 2012). EHMT1 and EHMT2 histone methyltransferases were shown to function as a heterodimer in vivo (Tachibana et al. 2005).

Literature References
PubMed ID Title Journal Year
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Takahashi, A, Imai, Y, Yamakoshi, K, Kuninaka, S, Ohtani, N, Yoshimoto, S, Hori, S, Tachibana, M, Anderton, E, Takeuchi, T, Shinkai, Y, Peters, G, Saya, H, Hara, E

Mol. Cell 2012
15774718 Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Tachibana, M, Ueda, J, Fukuda, M, Takeda, N, Ohta, T, Iwanari, H, Sakihama, T, Kodama, T, Hamakubo, T, Shinkai, Y

Genes Dev. 2005
Participants
Participant Of
Orthologous Events
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Reviewed
Created