Cdh1:APC/C complex binds EHMT1:EHMT2

Stable Identifier
R-HSA-3788725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cdh1 (FZR1) is able to bind both G9a (EHMT2) and GLP (EHMT1) (Takahashi et al. 2012). EHMT1 and EHMT2 histone methyltransferases were shown to function as a heterodimer in vivo (Tachibana et al. 2005).
Literature References
PubMed ID Title Journal Year
15774718 Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Iwanari, H, Shinkai, Y, Hamakubo, T, Ohta, T, Fukuda, M, Tachibana, M, Sakihama, T, Ueda, J, Takeda, N, Kodama, T

Genes Dev. 2005
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E

Mol. Cell 2012
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