Reactome | Cdh1:APC/C complex binds EHMT1:EHMT2

Cdh1:APC/C complex binds EHMT1:EHMT2

Stable Identifier

R-HSA-3788725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cdh1 (FZR1) is able to bind both G9a (EHMT2) and GLP (EHMT1) (Takahashi et al. 2012). EHMT1 and EHMT2 histone methyltransferases were shown to function as a heterodimer in vivo (Tachibana et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15774718	Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9 Iwanari, H, Shinkai, Y, Hamakubo, T, Ohta, T, Fukuda, M, Tachibana, M, Sakihama, T, Ueda, J, Takeda, N, Kodama, T	Genes Dev.	2005
22178396	DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E	Mol. Cell	2012