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POMC(1-241) [secretory granule lumen]
Stable Identifier
R-HSA-378943
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Corticotropin-lipotropin precursor, COLI_HUMAN, POMC
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9NX04
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Corticotropin cleavage from POMC (Homo sapiens)
POMC(1-241) [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01189 POMC
Gene Names
POMC
Chain
signal peptide:1-26, peptide:27-102, peptide:77-87, peptide:105-134, peptide:138-176, peptide:138-150, peptide:156-176, peptide:179-267, peptide:179-234, peptide:217-234, peptide:237-267, peptide:237-241
Reference Genes
BioGPS Gene:5443 POMC
COSMIC (genes):POMC POMC
CTD Gene:5443 POMC
dbSNP Gene:5443 POMC
ENSEMBL:ENSG00000115138 POMC
ENSEMBL_homo_sapiens_GENE:ENSG00000115138.11 POMC
HGNC:9201 POMC
KEGG Gene (Homo sapiens):5443 POMC
Monarch:5443 POMC
NCBI Gene:5443 POMC
OMIM:176830 POMC
UCSC:P01189 POMC
Reference Transcript
RefSeq:NM_001035256.2 POMC
RefSeq:NM_001319205.1 POMC
RefSeq:NM_000939.3 POMC
RefSeq:NM_001319204.1 POMC
Other Identifiers
11716427_a_at
16895337
205720_PM_at
205720_at
2544631
2544632
2544633
2544634
2544635
2544636
2544637
2544638
2544639
2544640
2544641
2544643
2544644
2544647
33711_at
4126575
5443
8050805
A_23_P5875
A_33_P3345036
GE61306
GO:0001664
GO:0003013
GO:0005102
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005975
GO:0006091
GO:0006351
GO:0006355
GO:0007165
GO:0007218
GO:0007267
GO:0008217
GO:0019722
GO:0023052
GO:0030141
GO:0031410
GO:0031781
GO:0031782
GO:0032098
GO:0032720
GO:0033059
GO:0034774
GO:0042593
GO:0043226
GO:0043950
GO:0045944
GO:0048018
GO:0050886
GO:0070873
GO:0070996
GO:0098772
GO:0140668
GO:1990680
GO:2000852
HMNXSV003041514
ILMN_1672899
ILMN_2403664
PH_hs_0000252
TC02001657.hg
TC02004119.hg
V01510_rna1_at
g4505948_3p_at
Participates
as an input of
Corticotropin cleavage from POMC (Homo sapiens)
Other forms of this molecule
POMC(138-176) [secretory granule lumen]
POMC(138-176) R236G [extracellular region]
POMC(138-176) E79* [extracellular region]
POMC(138-176) K25* [extracellular region]
POMC(138-176) [cytosol]
POMC(77-87) [extracellular region]
POMC(217-234) [extracellular region]
POMC(138-150) [extracellular region]
POMC(237-241) [extracellular region]
POMC(237-267) [extracellular region]
POMC(138-176) [extracellular region]
Inferred To
pomc [secretory granule lumen]
(Danio rerio)
pomc [secretory granule lumen]
(Xenopus tropicalis)
POMC(1-241) [secretory granule lumen]
(Gallus gallus)
POMC [secretory granule lumen]
(Bos taurus)
POMC [secretory granule lumen]
(Canis familiaris)
POMC [secretory granule lumen]
(Sus scrofa)
Pomc [secretory granule lumen]
(Mus musculus)
Pomc [secretory granule lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_001030333.1
,
NP_001306133.1
,
NP_000930.1
,
NP_001306134.1
OpenTargets
ENSG00000115138
HPA
ENSG00000115138-POMC
GeneCards
P01189
Ensembl
ENST00000380794
,
ENSP00000384092
,
ENSP00000264708
,
ENSP00000370171
,
ENST00000405623
,
ENSG00000115138
,
ENST00000395826
,
ENST00000264708
,
ENSP00000379170
PRO
P01189
Pharos - Targets
P01189
Orphanet
16448
HMDB Protein
HMDBP12759
PDB
7PIV
,
6TUB
,
7F54
,
7F53
,
4Y49
,
8F7Q
,
4XNH
,
4XPD
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.556
3
UniProt:Q9NX04 AIRIM
0.556
3
UniProt:O75031 HSF2B
0.556
6
UniProt:Q9UMX2-2 OAZ3
0.556
3
UniProt:Q8NI38 IKBD
0.556
3
UniProt:Q8N8Y2 ATP6V0D2
3
ATP6V0D2 [lysosomal membrane]
(R-HSA-9640179)
ATP6V0D2 [phagocytic vesicle membrane]
(R-HSA-1222586)
ATP6V0D2 [endosome membrane]
(R-HSA-912599)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.556
3
UniProt:Q7Z4H3 HDDC2
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:P62508-3 ESRRG
0.556
3
UniProt:Q7RTU4 BHA09
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
3
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