CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)

Stable Identifier
R-HSA-378978
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human chorionic gonadotropin is a glycoprotein hormone produced in pregnancy. Its role is to maintain progesterone production by preventing the disintegration of the corpus luteum of the ovary and thus sustain the growing foetus (Rull & Laan 2005). Gonadotropin comprises an alpha subunit (CGA), common to the pituitary gonadotropin hormones (LH, FSH and TSH) and a distinct beta subunit (CGB3), unique for each hormone which confers receptor and biological specificity. The subunits are bound by six intrachain disulfide bonds, required for dimer formation (Beebe et al. 1990)

Literature References
PubMed ID Title Journal Year
1688430 Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form

Beebe, JS, Mountjoy, K, Krzesicki, RF, Perini, F, Ruddon, RW

J Biol Chem 1990
16123088 Expression of beta-subunit of HCG genes during normal and failed pregnancy

Rull, K, Laan, M

Hum. Reprod. 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created