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CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)
Stable Identifier
R-HSA-378978
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)
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Human chorionic gonadotropin is a glycoprotein hormone produced in pregnancy. Its role is to maintain progesterone production by preventing the disintegration of the corpus luteum of the ovary and thus sustain the growing foetus (Rull & Laan 2005). Gonadotropin comprises an alpha subunit (CGA), common to the pituitary gonadotropin hormones (LH, FSH and TSH) and a distinct beta subunit (CGB3), unique for each hormone which confers receptor and biological specificity. The subunits are bound by six intrachain disulfide bonds, required for dimer formation (Beebe et al. 1990)
Literature References
PubMed ID
Title
Journal
Year
16123088
Expression of beta-subunit of HCG genes during normal and failed pregnancy
Laan, M
,
Rull, K
Hum. Reprod.
2005
1688430
Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form
Perini, F
,
Ruddon, RW
,
Krzesicki, RF
,
Beebe, JS
,
Mountjoy, K
J Biol Chem
1990
Participants
Input
CGA [extracellular region]
(Homo sapiens)
CGB3 [extracellular region]
(Homo sapiens)
Output
Gonadotropin [extracellular region]
(Homo sapiens)
Participates
as an event of
Glycoprotein hormones (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
Orthologous Events
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Danio rerio)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-11-29)
Created
Jassal, B (2008-10-01)
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