Reactome | ADCY7 [plasma membrane]

ADCY7 [plasma membrane]

Stable Identifier

R-HSA-379057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 7, ADCY7_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51828 ADCY7

Gene Names

ADCY7, KIAA0037

Chain

chain:1-1080

Reference Genes

BioGPS Gene:113 ADCY7

COSMIC (genes):ADCY7 ADCY7

CTD Gene:113 ADCY7

dbSNP Gene:113 ADCY7

ENSEMBL:ENSG00000121281 ADCY7

ENSEMBL_homo_sapiens_GENE:ENSG00000121281.13 ADCY7

HGNC:238 ADCY7

KEGG Gene (Homo sapiens):113 ADCY7

Monarch:113 ADCY7

NCBI Gene:113 ADCY7

OMIM:600385 ADCY7

UCSC:P51828 ADCY7

Reference Transcript

Other Identifiers

113

11720747_a_at

11746079_a_at

11755534_a_at

1554827_PM_a_at

1554827_a_at

16818773

203741_PM_s_at

203741_s_at

3659972

3659973

3659988

3659989

3659990

3659991

3659992

3659993

3659994

3659996

3659997

3659998

3659999

3660000

3660001

3660002

3660003

3660008

3660009

3660010

3660011

3660012

3660014

3660015

3660017

3660020

3660021

3660023

3660024

3660025

3660027

3660029

3660030

3660031

3660032

3660033

3660034

3660035

3660036

3660037

3660038

3660040

40585_at

7995492

A_14_P116595

A_23_P106945

A_24_P416177

D25538_at

GE57129

GO:0000166

GO:0002376

GO:0002819

GO:0003824

GO:0004016

GO:0005524

GO:0005886

GO:0006171

GO:0006954

GO:0007189

GO:0007193

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0022414

GO:0023052

GO:0035556

GO:0046872

GO:0055086

GO:0060135

GO:0071285

GO:0071361

GO:1900016

GO:1901135

HMNXSV003019830

Hs2.172199.2.S1_3p_s_at

ILMN_1655935

PH_hs_0010313

TC16000439.hg

g4557254_3p_at

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Homo sapiens)

as a member of

Adenylate cyclase [plasma membrane] (Homo sapiens)

Inferred To

acy-2 [plasma membrane] (Caenorhabditis elegans)

ADCY7 [plasma membrane] (Bos taurus)

ADCY7 [plasma membrane] (Canis familiaris)

ADCY7 [plasma membrane] (Dictyostelium discoideum)

ADCY7 [plasma membrane] (Gallus gallus)

ADCY7 [plasma membrane] (Mus musculus)

ADCY7 [plasma membrane] (Rattus norvegicus)

ADCY7 [plasma membrane] (Sus scrofa)

ADCY7 [plasma membrane] (Xenopus tropicalis)

ACXD [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_016878384.1, NP_001105.1

Guide to Pharmacology - Targets

1284

OpenTargets

ENSG00000121281

GeneCards

P51828

HPA

ENSG00000121281-ADCY7

Ensembl

ENST00000254235, ENST00000394697, ENSP00000378187, ENSG00000121281, ENST00000673801, ENSP00000254235, ENSP00000501053

PRO

P51828

Pharos - Targets

P51828

HMDB Protein

HMDBP00704

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