NID1 degradation by MMP19

Stable Identifier
R-HSA-3791319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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NID1 degradation by MMP19
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Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.
Literature References
PubMed ID Title Journal Year
10809722 Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme

Murphy, G, Knäuper, V, López-Otin, C, Stracke, JO, Hutton, M, Stewart, M, Pendás, AM, Smith, B

J. Biol. Chem. 2000
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Catalyst Activity

metalloendopeptidase activity of MMP19 [extracellular region]

Physical Entity
MMP19 [extracellular region] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
NID1 degradation by MMP19 (Bos taurus)
NID1 degradation by MMP19 (Canis familiaris)
NID1 degradation by MMP19 (Mus musculus)
NID1 degradation by MMP19 (Sus scrofa)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-07-05)
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