Reactome | NEDD1 [cytosol]

NEDD1 [cytosol]

Stable Identifier

R-HSA-379267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEDD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NHV4 NEDD1

Gene Names

NEDD1

Chain

chain:1-660

Reference Genes

BioGPS Gene:121441 NEDD1

COSMIC (genes):NEDD1 NEDD1

CTD Gene:121441 NEDD1

dbSNP Gene:121441 NEDD1

ENSEMBL:ENSG00000139350 NEDD1

HGNC:7723 NEDD1

KEGG:hsa:121441 NEDD1

Monarch:121441 NEDD1

NCBI Gene:121441 NEDD1

OMIM:600372 NEDD1

UCSC:Q8NHV4 NEDD1

Reference Transcript

Other Identifiers

11739545_s_at

11739546_a_at

11740287_a_at

11741727_a_at

121441

1552417_PM_a_at

1552417_a_at

1560116_PM_a_at

1560116_a_at

16755433

234984_3p_at

234984_PM_at

234984_at

3427353

3427354

3427355

3427356

3427358

3427360

3427361

3427362

3427363

3427366

3427367

3427368

3427369

3427370

3427372

3427373

3427374

3427376

3427377

3427387

3427388

3427389

3427390

3427391

3427392

3427394

58222_at

7957715

81540_at

A_14_P116323

A_24_P198355

A_33_P3260016

GE87465

GO:0000242

GO:0000278

GO:0000922

GO:0001650

GO:0005515

GO:0005654

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0007010

GO:0007020

GO:0008092

GO:0036064

GO:0043015

GO:0043226

GO:0045177

GO:0051301

HMNXSV003018452

Hs.14456.0.A1_3p_at

Hs2.14456.1.S1_3p_s_at

Hs2.14456.3.S1_3p_s_at

ILMN_1743208

ILMN_2206151

PH_hs_0001372

TC12000749.hg

Participates

as a component of

Inferred To

NEDD1 [cytosol] (Bos taurus)

NEDD1 [cytosol] (Canis familiaris)

NEDD1 [cytosol] (Gallus gallus)

NEDD1 [cytosol] (Sus scrofa)

Nedd1 [cytosol] (Mus musculus)

Nedd1 [cytosol] (Rattus norvegicus)

Ghost homologue of NEDD1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_690869.1, XP_006719300.1, XP_011536205.1, XP_005268701.1, NP_001128649.1, NP_001128647.1, NP_001128648.1

OpenTargets

ENSG00000139350

ENSEMBL

ENST00000266742, ENSP00000266742, ENSP00000411307, ENSG00000139350, ENST00000457368, ENST00000411739, ENSP00000451211, ENST00000429527, ENST00000557644, ENSP00000407964, ENSP00000404978

HPA

ENSG00000139350-NEDD1

GeneCards

NEDD1

PRO

Q8NHV4

Pharos - Targets

Q8NHV4

GlyGen

Q8NHV4

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43303 CCP110	2	CCP110 [cytosol] (R-HSA-380261) PolyUb-CCP110 [cytosol] (R-HSA-6783044)	0.619	3
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.615	3
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.527	2
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.483	2

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