SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

Stable Identifier
R-HSA-379415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
ReviewStatus
5/5
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SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
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SLC7A7 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine (L-Arg) for leucine (L-Leu) and a sodium ion (Na+). The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is predominantly expressed in the kidney (Pfeiffer et al. 2000).
Literature References
PubMed ID Title Journal Year
9878049 Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family

Pfeiffer, R, Verrey, F, Rossier, G, Kühn, L, Spindler, B, Meier, C

EMBO J 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A7:SLC3A2 heterodimer [plasma membrane]

Physical Entity
SLC7A7:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)
SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Jassal, B  (2008-11-26)
Created
D'Eustachio, P  (2008-10-29)
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