Reactome | IARS2 [mitochondrial matrix]

IARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Isoleucyl-tRNA synthetase 2

Locations in the PathwayBrowser for interactor UniProt:Q8IWL3 HSCB

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External Reference Information

External Reference

UniProt:Q9NSE4 IARS2

Gene Names

IARS2

Chain

transit peptide:1-48, chain:49-1012

Reference Genes

BioGPS Gene:55699 IARS2

COSMIC (genes):IARS2 IARS2

CTD Gene:55699 IARS2

dbSNP Gene:55699 IARS2

ENSEMBL:ENSG00000067704 IARS2

HGNC:29685 IARS2

Monarch:55699 IARS2

NCBI Gene:55699 IARS2

OMIM:612801 IARS2

UCSC:Q9NSE4 IARS2

Reference Transcript

RefSeq:NM_018060.3 IARS2

Other Identifiers

11717307_s_at

16677616

217900_PM_at

217900_at

2380997

2380998

2380999

2381000

2381003

2381004

2381005

2381006

2381007

2381008

2381009

2381010

2381011

2381012

2381013

2381014

2381015

2381020

2381022

2381024

2381026

2381028

2381029

2381031

2381032

2381033

2381037

2381038

2381039

2381040

2381041

2381042

2381044

2381045

2381046

2381047

2381048

36647_at

55699

7909815

A_23_P74843

A_32_P19019

GE61543

GO:0000049

GO:0000166

GO:0002161

GO:0003723

GO:0003824

GO:0004812

GO:0004822

GO:0005524

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006428

GO:0006520

GO:0016787

GO:0016874

GO:0032543

GO:0043226

GO:0106074

GO:0140098

HMNXSV003058330

ILMN_1671207

PH_hs_0013636

TC01001814.hg

g8922355_3p_at

Participates

as a member of

Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)

Inferred To

IleRS-m [mitochondrial matrix] (Drosophila melanogaster)

Iars2 [mitochondrial matrix] (Rattus norvegicus)

iars-2 [mitochondrial matrix] (Caenorhabditis elegans)

IARS2 [mitochondrial matrix] (Bos taurus)

IARS2 [mitochondrial matrix] (Canis familiaris)

IARS2 [mitochondrial matrix] (Dictyostelium discoideum)

IARS2 [mitochondrial matrix] (Gallus gallus)

IARS2 [mitochondrial matrix] (Mus musculus)

IARS2 [mitochondrial matrix] (Saccharomyces cerevisiae)

IARS2 [mitochondrial matrix] (Schizosaccharomyces pombe)

IARS2 [mitochondrial matrix] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000355889, ENST00000366922

OpenTargets

ENSG00000067704

HPA

ENSG00000067704-IARS2

PRO

Q9NSE4

Pharos - Targets

Q9NSE4

GlyGen

Q9NSE4

Orphanet

IARS2

HMDB Protein

HMDBP10675

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	4
UniProt:Q8N6W0 CELF5			0.527	3
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:P58557 YBEY			0.527	2
UniProt:O14976 GAK	3	GAK [cytosol] (R-HSA-8868619) GAK [Golgi membrane] (R-HSA-434340) GAK [cytoplasmic vesicle membrane] (R-HSA-434203)	0.527	2
UniProt:Q8IZT6 ASPM			0.527	2
UniProt:Q9H765 ASB8	1	ASB8 [cytosol] (R-HSA-975422)	0.527	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.527	2
UniProt:P54764 EPHA4	2	p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352) EPHA4 [plasma membrane] (R-HSA-2682325)	0.527	2
UniProt:Q83D60 Q83D60			0.488	2
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.462	2

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