Reactome | AIMP2 [cytosol]

AIMP2 [cytosol]

Stable Identifier

R-HSA-379576

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

JTV1, Multisynthetase complex auxiliary component p38

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13155 AIMP2

Gene Names

AIMP2, JTV1, PRO0992

Chain

chain:1-320

Reference Genes

BioGPS Gene:7965 AIMP2

COSMIC (genes):AIMP2 AIMP2

CTD Gene:7965 AIMP2

dbSNP Gene:7965 AIMP2

ENSEMBL:ENSG00000106305 AIMP2

ENSEMBL:ENSG00000106305.10 AIMP2

HGNC:20609 AIMP2

KEGG Gene (Homo sapiens):7965 AIMP2

Monarch:7965 AIMP2

NCBI Gene:7965 AIMP2

OMIM:600859 AIMP2

UCSC:Q13155 AIMP2

Reference Transcript

Other Identifiers

11716562_at

11716563_s_at

17043355

202138_PM_x_at

202138_x_at

209971_PM_x_at

209971_x_at

2988883

2988884

2988888

2988890

2988893

2988894

2988895

2988896

3055824

3056740

41250_at

7965

8131374

A_14_P121031

A_23_P70991

GE79136

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006412

GO:0006915

GO:0008285

GO:0012501

GO:0016020

GO:0016567

GO:0017101

GO:0030154

GO:0031398

GO:0036211

GO:0043226

GO:0048856

GO:0060090

GO:0060510

GO:0065003

GO:1903632

HMNXSV003057418

Hs.258730.1.S1_3p_s_at

ILMN_1673252

TC07000059.hg

U24169_at

g7959732_RC_3p_a_at

Participates

as a component of

aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001313536.1, NP_006294.2

OpenTargets

ENSG00000106305

HPA

ENSG00000106305-AIMP2

GeneCards

Q13155

Ensembl

ENSP00000223029, ENST00000395236, ENSG00000106305, ENST00000223029, ENSP00000378658

PRO

Q13155

Pharos - Targets

Q13155

Orphanet

28740

PDB

6K39, 6JPV, 6ILD, 5A1N, 5A34, 6IY6, 4YCW, 5A5H, 5Y6L, 4DPG, 4YCU

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.718	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.593	6
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.577	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.556	5
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	5
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P03508 NS	5	NEP/NS2 [extracellular region] (R-FLU-169705) NEP/NS2 [endocytic vesicle membrane] (R-FLU-189148) NEP/NS2 [endosome lumen] (R-FLU-189176) NEP/NS2 [cytosol] (R-FLU-192845) NEP/NS2 [nucleoplasm] (R-FLU-169474)	0.553	2

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